UniProt Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Q04631)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (UniProt Q04631), EC 2.5.1.58, 2.5.1.59: 104 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 38 pockets. Binding sites…
- UniProt
- Q04631
- Protein
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- EC
- 2.5.1.58, 2.5.1.59
- Experimental structures
- 104
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 38 · 3 records with a druggable one
Structures
105 records of Q04631 in the MolNFT archive: 104 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1D8D | Co-crystal structure of rat protein farnesyltransferase complexed with a K-RAS4B peptide substrate… | x-ray diffraction | A | — | — |
| 1D8D | Co-crystal structure of rat protein farnesyltransferase complexed with a K-RAS4B peptide substrate… | x-ray diffraction | A | — | — |
| 1D8E | Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog. | x-ray diffraction | A | — | — |
| 1D8E | Zinc-depleted ftase complexed with K-RAS4B peptide substrate and fpp analog. | x-ray diffraction | A | — | — |
| 1FPP | Protein farnesyltransferase complex with farnesyl diphosphate | x-ray diffraction | A | — | — |
| 1FPP | Protein farnesyltransferase complex with farnesyl diphosphate | x-ray diffraction | A | — | — |
| 1FT1 | Crystal structure of protein farnesyltransferase at 2.25 ångströms resolution | x-ray diffraction | A | — | — |
| 1FT1 | Crystal structure of protein farnesyltransferase at 2.25 ångströms resolution | x-ray diffraction | A | — | — |
| 1FT2 | Co-crystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate | x-ray diffraction | A | — | — |
| 1FT2 | Co-crystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate | x-ray diffraction | A | — | — |
| 1JCR | Crystal structure of rat protein farnesyltransferase complexed with the non-substrate tetrapeptide… | x-ray diffraction | A | — | — |
| 1JCR | Crystal structure of rat protein farnesyltransferase complexed with the non-substrate tetrapeptide… | x-ray diffraction | A | — | — |
| 1JCS | Crystal structure of rat protein farnesyltransferase complexed with the peptide substrate tkcvfm… | x-ray diffraction | A | — | — |
| 1JCS | Crystal structure of rat protein farnesyltransferase complexed with the peptide substrate tkcvfm… | x-ray diffraction | A | — | — |
| 1KZO | Protein farnesyltransferase complexed with farnesylated K-RAS4B peptide product and farnesyl… | x-ray diffraction | A | — | — |
| 1KZO | Protein farnesyltransferase complexed with farnesylated K-RAS4B peptide product and farnesyl… | x-ray diffraction | A | — | — |
| 1KZP | Protein farnesyltransferase complexed with a farnesylated K-RAS4B peptide product | x-ray diffraction | A | — | — |
| 1KZP | Protein farnesyltransferase complexed with a farnesylated K-RAS4B peptide product | x-ray diffraction | A | — | — |
| 1N4P | Protein Geranylgeranyltransferase type-I Complexed with Geranylgeranyl Diphosphate | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1N4P | Protein geranylgeranyltransferase type-I complexed with geranylgeranyl diphosphate | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1N4Q | Protein Geranylgeranyltransferase type-I Complexed with a GGPP Analog and a KKKSKTKCVIL Peptide | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1N4Q | Protein geranylgeranyltransferase type-I complexed with a ggpp analog and a kkksktkcvil peptide | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1N4R | Protein Geranylgeranyltransferase type-I Complexed with a Geranylgeranylated KKKSKTKCVIL Peptide… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1N4R | Protein geranylgeranyltransferase type-I complexed with a geranylgeranylated kkksktkcvil peptide… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1N4S | Protein Geranylgeranyltransferase type-I Complexed with GGPP and a Geranylgeranylated KKKSKTKCVIL… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1N4S | Protein geranylgeranyltransferase type-I complexed with ggpp and a geranylgeranylated kkksktkcvil… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1N94 | Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine… | x-ray diffraction | A | — | — |
| 1N94 | Aryl tetrahydropyridine inhbitors of farnesyltransferase: glycine, phenylalanine and histidine… | x-ray diffraction | A | — | — |
| 1N95 | Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine… | x-ray diffraction | A | — | — |
| 1N95 | Aryl tetrahydrophyridine inhbitors of farnesyltranferase: glycine, phenylalanine and histidine… | x-ray diffraction | A | — | — |
| 1N9A | Farnesyltransferase complex with tetrahydropyridine inhibitors | x-ray diffraction | A | — | — |
| 1N9A | Farnesyltransferase complex with tetrahydropyridine inhibitors | x-ray diffraction | A | — | — |
| 1NI1 | Imidazole and cyanophenyl farnesyl transferase inhibitors | x-ray diffraction | A | — | — |
| 1NI1 | Imidazole and cyanophenyl farnesyl transferase inhibitors | x-ray diffraction | A | — | — |
| 1NL4 | Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor | x-ray diffraction | A | — | — |
| 1NL4 | Crystal structure of rat farnesyl transferase in complex with a potent biphenyl inhibitor | x-ray diffraction | A | — | — |
| 1O1R | Structure of FPT bound to GGPP | x-ray diffraction | A | — | — |
| 1O1R | Structure of fpt bound to ggpp | x-ray diffraction | A | — | — |
| 1O1S | Structure of FPT bound to isoprenoid analog 3b | x-ray diffraction | A | — | — |
| 1O1S | Structure of fpt bound to isoprenoid analog 3B | x-ray diffraction | A | — | — |
| 1O1T | Structure of FPT bound to the CVIM-FPP product | x-ray diffraction | A | — | — |
| 1O1T | Structure of fpt bound to the cvim-fpp product | x-ray diffraction | A | — | — |
| 1O5M | Structure of FPT bound to the inhibitor SCH66336 | x-ray diffraction | A | — | — |
| 1O5M | Structure of fpt bound to the inhibitor SCH66336 | x-ray diffraction | A | — | — |
| 1QBQ | Structure of rat farnesyl protein transferase complexed with a cvim peptide and… | x-ray diffraction | A | — | — |
| 1QBQ | Structure of rat farnesyl protein transferase complexed with a cvim peptide and… | x-ray diffraction | A | — | — |
| 1S64 | Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1S64 | Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1SA5 | Rat protein farnesyltransferase complexed with FPP and BMS-214662 | x-ray diffraction | A | — | — |
| 1SA5 | Rat protein farnesyltransferase complexed with fpp and bms- 214662 | x-ray diffraction | A | — | — |
| 1TN7 | Protein Farnesyltransferase Complexed with a TC21 Peptide Substrate and a FPP Analog at 2.3A… | x-ray diffraction | A | — | — |
| 1TN7 | Protein farnesyltransferase complexed with a TC21 peptide substrate and a fpp analog at 2.3A… | x-ray diffraction | A | — | — |
| 1TN8 | Protein Farnesyltransferase Complexed with a H-Ras Peptide Substrate and a FPP Analog at 2.25A… | x-ray diffraction | A | — | — |
| 1TN8 | Protein farnesyltransferase complexed with a H-RAS peptide substrate and a fpp analog at 2.25A… | x-ray diffraction | A | — | — |
| 1TNB | Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a substrate… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1TNB | Rat protein geranylgeranyltransferase type-I complexed with a ggpp analog and a substrate… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1TNO | Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a KKKSKTKCVIM Peptide… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1TNO | Rat protein geranylgeranyltransferase type-I complexed with a ggpp analog and a kkksktkcvim peptide… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1TNU | Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a GCINCCKVL Peptide… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1TNU | Rat protein geranylgeranyltransferase type-I complexed with a ggpp analog and a gcincckvl peptide… | x-ray diffraction | A, C, E, G, I, K | — | — |
45 records more on the page itself.
Ligands
- 60I · [4-[[3-(2,2-dimethylpropyl)-1~{H}-benzimidazol-2-yl]methyl]piperazin-1-yl]-(1,3,5-trimethylpyrazol-4-yl)methanone · in 4 records
- ACE · Acetyl group · in 4 records
- DMA · Dimethylallyl diphosphate · in 2 records
- MG · Magnesium ion · in 2 records
- PPV · Pyrophosphate · in 2 records
- A1HZ4 · (5~{R})-5-(2-methoxyphenyl)-9-[(2~{R})-3,3,3-tris(fluoranyl)-2-methoxy-2-phenyl-propanoyl]-3,9-diazaspiro[5.5]undecan-2-one · in 1 record
- DPO · Diphosphate · in 1 record
- FPP · Farnesyl diphosphate · in 1 record
- XMY · (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one · in 1 record
Experiment against prediction
- 1O1R chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.44 Å
- 1O1R chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.44 Å
- 1O1T chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.44 Å
- 1O1T chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.44 Å
- 1O5M chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.44 Å
- 1O5M chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.44 Å
- 2ZIR chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.44 Å
- 2ZIR chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.44 Å
- 1O1S chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.45 Å
- 1O1S chain A against the predicted model Q04631: TM-score 1.00, RMSD 0.45 Å
Elsewhere
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