Ligand · 3PZ

3PZ · (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

3PZ, (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile (C29 H29 N5 O3 S, 527.6 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB…

Component: 3PZ
Formula: C29 H29 N5 O3 S
Class: ligand
Structures: 6
PDB entries: 3

Binding sites

3PZ in 6 structures; the first of them:

3PZ1 · Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 · 3PZ B1 · binds ASP61, TYR44, LEU45, TRP52, ASP238, CYS240, TRP244, ASP287 and 3 more
3PZ2 · Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid… · 3PZ B333 · binds ASP61, TYR107, TYR44, LEU45, TRP52, ASP238, CYS240, TRP244 and 4 more
3PZ4 · Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3… · 3PZ B429 · binds TYR93, CYS95, LEU96, TRP102, TRP106, ASP297, CYS299, TRP303 and 5 more
3PZ1 · Crystal structure of RABGGTASE(DELTA lrr; delta ig) in complex with BMS3 · 3PZ B1 · binds ASP61, TYR44, LEU45, TRP52, ASP238, CYS240, TRP244, ASP287 and 3 more
3PZ2 · Crystal structure of RABGGTASE(DELTA lrr; delta ig) in complex with BMS3 and lipid… · 3PZ B333 · binds ASP61, TYR107, TYR44, LEU45, TRP52, ASP238, CYS240, TRP244 and 4 more
3PZ4 · Crystal structure of FTASE(ALPHA-subunit; beta-subunit delta C10) in complex with BMS3… · 3PZ B429 · binds TYR93, CYS95, LEU96, TRP102, TRP106, ASP297, CYS299, TRP303 and 5 more

Residues it binds most

ASP 6, TRP 6, TYR 6, CYS 6, HIS 6, LEU 6, PHE 6, PRO 4 (residue and the binding sites it lines).

Found with

ZN · Zinc ion
CA · Calcium ion
FPP · Farnesyl diphosphate
GRG · Geranylgeranyl diphosphate
DMS · Dimethyl sulfoxide

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