MolNFT v1 · #75122 · protein
Crystal structure of human U1 snrnp
3PGW · U1-a: “Crystal structure of human U1 snrnp”. X-ray diffraction, 3 pockets (best druggability 0.32). MolNFT v1 #75122 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3PGW
- Type
- protein
- Length
- 1,716 residues
- Chains
- 18
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U1-a; U1-70K; Sm-D3; Sm B; Sm-D1; Sm-D2; Sm-F; Sm-E; Sm G
- UniProt
- P09012, P08621, P62318, Q66K91, P62314, P62316, P62306, P62304, D6W5G6
- Pockets
- 3 · best druggability 0.32
Structure
x-ray diffraction · 16 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | U1-a | protein | 108 | 0% helix, 0% strand | P09012 |
| S | U1-70K | protein | 150 | 0% helix, 0% strand | P08621 |
| Z | Sm-D3 | protein | 80 | 0% helix, 0% strand | P62318 |
| B | Sm B | protein | 81 | 0% helix, 0% strand | Q66K91 |
| X, U | Sm-D1 | protein | 85 | 0% helix, 0% strand | P62314 |
| Y | Sm-D2 | protein | 111 | 0% helix, 0% strand | P62316 |
| F | Sm-F | protein | 85 | 0% helix, 0% strand | P62306 |
| E | Sm-E | protein | 84 | 0% helix, 0% strand | P62304 |
| G, J | Sm G | protein | 76 | 0% helix, 0% strand | D6W5G6 |
| P | U1-a | protein | 113 | 0% helix, 0% strand | P09012 |
| L | U1-70K | protein | 148 | 0% helix, 0% strand | P08621 |
| W | Sm-D3 | protein | 92 | 0% helix, 0% strand | P62318 |
| Q | Sm B | protein | 76 | 0% helix, 0% strand | Q66K91 |
| V | Sm-D2 | protein | 103 | 0% helix, 0% strand | P62316 |
| I | Sm-F | protein | 74 | 0% helix, 0% strand | P62306 |
| H | Sm-E | protein | 89 | 0% helix, 0% strand | P62304 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.32 | 0.72 | 22 | empty |
| 2 | 50 | 0.28 | 0.73 | 17 | empty |
| 3 | 50 | 0.27 | 0.73 | 14 | empty |
Interfaces
20 interfaces between chains.
- Y–F · 153 Ų buried · 0 hydrogen bonds · protein-protein
- F–E · 140 Ų buried · 0 hydrogen bonds · protein-protein
- V–I · 140 Ų buried · 0 hydrogen bonds · protein-protein
- I–H · 139 Ų buried · 0 hydrogen bonds · protein-protein
- W–Q · 126 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3PGW · Crystal structure of human U1 snRNP · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09012
- Every structure of UniProt P08621
- Every structure of UniProt P62318
- Every structure of UniProt Q66K91
- Every structure of UniProt P62314
- Every structure of UniProt P62316
- Every structure of UniProt P62306
- Every structure of UniProt P62304
- Every structure of UniProt D6W5G6
- Elsewhere: RCSB PDB 3PGW · PDBe 3PGW · UniProt P09012 · UniProt P08621 · UniProt P62318 · UniProt Q66K91 · UniProt P62314 · UniProt P62316 · UniProt P62306 · UniProt P62304 · UniProt D6W5G6
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