UniProt P09012
U1 small nuclear ribonucleoprotein A (P09012)
U1 small nuclear ribonucleoprotein A (UniProt P09012): 164 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 80 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P09012
- Protein
- U1 small nuclear ribonucleoprotein A
- Experimental structures
- 164
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 80 · 13 records with a druggable one
Structures
165 records of P09012 in the MolNFT archive: 164 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AUD | U1A-utrrna, NMR, 31 structures | solution nmr | A | — | — |
| 1AUD | U1A-utrrna, NMR, 31 structures | solution nmr | A | — | — |
| 1DRZ | U1A spliceosomal PROTEIN/HEPATITIS delta virus genomic ribozyme complex | x-ray diffraction | A | — | — |
| 1DRZ | U1A spliceosomal PROTEIN/HEPATITIS delta virus genomic ribozyme complex | x-ray diffraction | A | — | — |
| 1DZ5 | The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of cooperativity in… | solution nmr | A, B | — | — |
| 1DZ5 | The NMR structure of the 38KDA U1A protein-pie RNA complex reveals the basis of cooperativity in… | solution nmr | A, B | — | — |
| 1FHT | RNA-binding domain of the U1A spliceosomal protein U1A117, NMR, 43 structures | solution nmr | A | — | — |
| 1FHT | RNA-binding domain of the U1A spliceosomal protein U1A117, NMR, 43 structures | solution nmr | A | — | — |
| 1M5K | Crystal structure of a hairpin ribozyme in the catalytically-active conformation | x-ray diffraction | C, F | — | — |
| 1M5K | Crystal structure of a hairpin ribozyme in the catalytically-active conformation | x-ray diffraction | C, F | — | — |
| 1M5O | Transition State Stabilization by a Catalytic RNA | x-ray diffraction | C, F | — | — |
| 1M5O | Transition state stabilization by a catalytic RNA | x-ray diffraction | C, F | — | — |
| 1M5P | Transition State Stabilization by a Catalytic RNA | x-ray diffraction | C, F | — | — |
| 1M5P | Transition state stabilization by a catalytic RNA | x-ray diffraction | C, F | — | — |
| 1M5V | Transition State Stabilization by a Catalytic RNA | x-ray diffraction | C, F | — | — |
| 1M5V | Transition state stabilization by a catalytic RNA | x-ray diffraction | C, F | — | — |
| 1NU4 | U1A RNA binding domain at 1.8 angstrom resolution reveals a pre-organized C-terminal helix | x-ray diffraction | A, B | — | — |
| 1NU4 | U1A RNA binding domain at 1.8 ångström resolution reveals a pre- organized C-terminal helix | x-ray diffraction | A, B | — | — |
| 1OIA | U1A rnp domain 1-95 | x-ray diffraction | A, B | — | — |
| 1OIA | U1A rnp domain 1-95 | x-ray diffraction | A, B | — | — |
| 1SJ3 | Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound | x-ray diffraction | P | — | — |
| 1SJ3 | Hepatitis delta virus gemonic ribozyme precursor, with MG2+ bound | x-ray diffraction | P | — | — |
| 1SJ4 | Crystal structure of a C75U mutant Hepatitis Delta Virus ribozyme precursor, in Cu2+ solution | x-ray diffraction | P | — | — |
| 1SJ4 | Crystal structure of a C75U mutant hepatitis delta virus ribozyme precursor, in CU2+ solution | x-ray diffraction | P | — | — |
| 1SJF | Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in… | x-ray diffraction | A | — | — |
| 1SJF | Crystal structure of the hepatitis delta virus gemonic ribozyme precursor, with C75U mutaion, in… | x-ray diffraction | A | — | — |
| 1U6B | Crystal structure of a self-splicing group I intron with both exons | x-ray diffraction | A | — | — |
| 1U6B | Crystal structure of a self-splicing group I intron with both exons | x-ray diffraction | A | — | — |
| 1URN | U1A MUTANT/RNA complex + glycerol | x-ray diffraction | A, B, C | — | — |
| 1URN | U1A MUTANT/RNA complex + glycerol | x-ray diffraction | A, B, C | — | — |
| 1VBX | Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in… | x-ray diffraction | A | — | — |
| 1VBX | Crystal structure of the hepatitis delta virus gemonic ribozyme precursor, with C75U mutaion, in… | x-ray diffraction | A | — | — |
| 1VBY | Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, and… | x-ray diffraction | A | — | — |
| 1VBY | Crystal structure of the hepatitis delta virus gemonic ribozyme precursor, with C75U mutaion, and… | x-ray diffraction | A | — | — |
| 1VBZ | Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in… | x-ray diffraction | A | — | — |
| 1VBZ | Crystal structure of the hepatitis delta virus gemonic ribozyme precursor, with C75U mutaion, in… | x-ray diffraction | A | — | — |
| 1VC0 | Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in… | x-ray diffraction | A | — | — |
| 1VC0 | Crystal structure of the hepatitis delta virus gemonic ribozyme precursor, with C75U mutaion, in… | x-ray diffraction | A | — | — |
| 1VC5 | Crystal Structure of the Wild Type Hepatitis Delta Virus Gemonic Ribozyme Precursor, in EDTA… | x-ray diffraction | A | — | — |
| 1VC5 | Crystal structure of the wild type hepatitis delta virus gemonic ribozyme precursor, in edta… | x-ray diffraction | A | — | — |
| 1VC6 | Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Product with C75U Mutaion, cleaved… | x-ray diffraction | A | — | — |
| 1VC6 | Crystal structure of the hepatitis delta virus gemonic ribozyme product with C75U mutaion, cleaved… | x-ray diffraction | A | — | — |
| 1ZZN | Crystal structure of a group I intron/two exon complex that includes all catalytic metal ion… | x-ray diffraction | A | — | — |
| 1ZZN | Crystal structure of a group I INTRON/TWO exon complex that includes all catalytic metal ion… | x-ray diffraction | A | — | — |
| 2A3J | Structure of URNdesign, a complete computational redesign of human U1A protein | solution nmr | A | — | — |
| 2A3J | Structure of urndesign, a complete computational redesign of human U1A protein | solution nmr | A | — | — |
| 2NZ4 | Structural investigation of the GlmS ribozyme bound to its catalytic cofactor | x-ray diffraction | A, B, C, D | — | — |
| 2NZ4 | Structural investigation of the glms ribozyme bound to its catalytic cofactor | x-ray diffraction | A, B, C, D | — | — |
| 2OIH | Hepatitis Delta Virus gemonic ribozyme precursor with C75U mutation and bound to monovalent cation… | x-ray diffraction | A | — | — |
| 2OIH | Hepatitis delta virus gemonic ribozyme precursor with C75U mutation and bound to monovalent cation… | x-ray diffraction | A | — | — |
| 2OJ3 | Hepatitis Delta Virus ribozyme precursor structure, with C75U mutation, bound to Tl+ and cobalt… | x-ray diffraction | A | — | — |
| 2OJ3 | Hepatitis delta virus ribozyme precursor structure, with C75U mutation, bound to tl+ and cobalt… | x-ray diffraction | A | — | — |
| 2U1A | RNA binding domain 2 of human U1A protein, NMR, 20 structures | solution nmr | A | — | — |
| 2U1A | RNA binding domain 2 of human U1A protein, NMR, 20 structures | solution nmr | A | — | — |
| 3BO2 | A relaxed active site following exon ligation by a group I intron | x-ray diffraction | A | — | — |
| 3BO2 | A relaxed active site following exon ligation by a group I intron | x-ray diffraction | A | — | — |
| 3BO3 | A relaxed active site following exon ligation by a group I intron | x-ray diffraction | A | — | — |
| 3BO3 | A relaxed active site following exon ligation by a group I intron | x-ray diffraction | A | — | — |
| 3BO4 | A relaxed active site following exon ligation by a group I intron | x-ray diffraction | A | — | — |
| 3BO4 | A relaxed active site following exon ligation by a group I intron | x-ray diffraction | A | — | — |
105 records more on the page itself.
Ligands
Experiment against prediction
- 1M5O chain C against the predicted model P09012: TM-score 0.99, RMSD 0.34 Å
- 3G8T chain D against the predicted model P09012: TM-score 0.99, RMSD 0.33 Å
- 2NZ4 chain A against the predicted model P09012: TM-score 0.99, RMSD 0.34 Å
- 3EGZ chain A against the predicted model P09012: TM-score 0.99, RMSD 0.36 Å
- 6LAX chain E against the predicted model P09012: TM-score 0.99, RMSD 0.37 Å
- 2NZ4 chain C against the predicted model P09012: TM-score 0.99, RMSD 0.36 Å
- 6LAX chain C against the predicted model P09012: TM-score 0.99, RMSD 0.37 Å
- 3R1L chain A against the predicted model P09012: TM-score 0.99, RMSD 0.37 Å
- 3G9C chain A against the predicted model P09012: TM-score 0.99, RMSD 0.36 Å
- 6LAS chain E against the predicted model P09012: TM-score 0.99, RMSD 0.37 Å
Elsewhere
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