UniProt P08621
U1 small nuclear ribonucleoprotein 70 kDa (P08621)
U1 small nuclear ribonucleoprotein 70 kDa (UniProt P08621): 17 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08621
- Protein
- U1 small nuclear ribonucleoprotein 70 kDa
- Experimental structures
- 17
- Predicted models
- 1
- Pockets
- 10 · 5 records with a druggable one
Structures
18 records of P08621 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2L5I | structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form) | solution nmr | A | — | — |
| 2L5I | Structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form) | solution nmr | A | — | — |
| 2L5J | structure of the spliceosomal phosphopeptide P140 (phosphorylated form) | solution nmr | A | — | — |
| 2L5J | Structure of the spliceosomal phosphopeptide P140 (phosphorylated form) | solution nmr | A | — | — |
| 3CW1 | Crystal Structure of Human Spliceosomal U1 snRNP | x-ray diffraction | K, 6, 7, 8 | — | — |
| 3CW1 | Crystal structure of human spliceosomal U1 snrnp | x-ray diffraction | K, 6, 7, 8 | — | — |
| 3PGW | Crystal structure of human U1 snRNP | x-ray diffraction | S, L | — | — |
| 3PGW | Crystal structure of human U1 snrnp | x-ray diffraction | S, L | — | — |
| 4PJO | Minimal U1 snRNP | x-ray diffraction | K, k, N, n | — | — |
| 4PJO | Minimal U1 snrnp | x-ray diffraction | K, k, N, n | — | — |
| 4PKD | U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2 | x-ray diffraction | B | — | — |
| 4PKD | U1-70K in complex with U1 snrna stem-loops 1 and U1-a rrm in complex with stem-loop 2 | x-ray diffraction | B | — | — |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | 1K | — | 1 (best 0.86) |
| 7B0Y | Structure of a transcribing RNA polymerase II-U1 snRNP complex | electron microscopy | b | — | 3 (best 0.83) |
| 7B0Y | Structure of a transcribing RNA polymerase II-U1 snrnp complex | electron microscopy | b | — | — |
| 7VPX | The cryo-EM structure of the human pre-A complex | electron microscopy | O | — | 3 (best 0.85) |
| 8R08 | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | electron microscopy | 1K | — | 1 (best 0.83) |
| P08621 | AlphaFold monomer V2.0 prediction for U1 small nuclear ribonucleoprotein 70 kda (P08621) | predicted | A | — | 2 (best 0.71) |
Experiment against prediction
- 7B0Y chain b against the predicted model P08621: TM-score 0.78, RMSD 2.20 Å
- 7B0Y chain b against the predicted model P08621: TM-score 0.78, RMSD 2.20 Å
- 3PGW chain S against the predicted model P08621: TM-score 0.74, RMSD 2.42 Å
- 3PGW chain S against the predicted model P08621: TM-score 0.74, RMSD 2.42 Å
- 3CW1 chain K against the predicted model P08621: TM-score 0.73, RMSD 2.38 Å
- 3CW1 chain K against the predicted model P08621: TM-score 0.73, RMSD 2.38 Å
- 6QX9 chain 1K against the predicted model P08621: TM-score 0.72, RMSD 1.88 Å
- 7VPX chain O against the predicted model P08621: TM-score 0.72, RMSD 1.88 Å
- 3PGW chain L against the predicted model P08621: TM-score 0.71, RMSD 2.67 Å
- 3PGW chain L against the predicted model P08621: TM-score 0.71, RMSD 2.67 Å
Elsewhere
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