Cfms tyrosine kinase in complex with 4-cyano-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-yl-phenyl)-amide

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 18% strand (DSSP).

Ligands and binding sites

• KRJ · 4-cyano-N-(2-cyclohex-1-en-1-yl-4-piperidin-4-ylphenyl)-1H-imidazole-2-carboxamide · ligand · chains A
• ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 3KRJ · cFMS tyrosine kinase in complex with 4-Cyano-1H-imidazole-2-carboxylic acid… · the same entry in another collection · chain A against A, TM-score 1.00
• P07333 · AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 receptor… · a predicted model of the same protein · chain A against A, TM-score 0.92
• P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P07333
• Every structure of UniProt P11362
• Elsewhere: RCSB PDB 3KRJ · PDBe 3KRJ · UniProt P07333 · UniProt P11362