MolNFT v1 · #68360 · protein
Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator
3JTL · Proteasome subunit alpha: “Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #68360 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3JTL
- Type
- protein
- Length
- 4,536 residues
- Chains
- 21
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha; Proteasome subunit beta; Proteasome activator protein PA26
- EC
- 3.4.25.1
- UniProt
- P25156, P28061, Q9U8G2
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 48% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Proteasome subunit alpha (EC 3.4.25.1) | protein | 227 | 33% helix, 26% strand | P25156 |
| H, I, J, K, L, M, N | Proteasome subunit beta (EC 3.4.25.1) | protein | 203 | 37% helix, 30% strand | P28061 |
| O, P, Q, R, S, T, U | Proteasome activator protein PA26 | protein | 218 | 73% helix, 1% strand | Q9U8G2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1136 | 0.80 | 0.81 | 136 | empty |
| 2 | 1174 | 0.80 | 0.81 | 139 | empty |
| 3 | 868 | 0.78 | 0.81 | 107 | empty |
| 4 | 864 | 0.76 | 0.80 | 105 | empty |
| 5 | 549 | 0.75 | 0.83 | 81 | empty |
Interfaces
56 interfaces between chains.
- S–T · 2193 Ų buried · 38 hydrogen bonds · protein-protein
- Q–R · 2172 Ų buried · 34 hydrogen bonds · protein-protein
- P–Q · 2172 Ų buried · 34 hydrogen bonds · protein-protein
- O–P · 2171 Ų buried · 34 hydrogen bonds · protein-protein
- R–S · 2160 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 3JTL · Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator · the same entry in another collection · chain U against U, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25156
- Every structure of UniProt P28061
- Every structure of UniProt Q9U8G2
- Elsewhere: RCSB PDB 3JTL · PDBe 3JTL · UniProt P25156 · UniProt P28061 · UniProt Q9U8G2
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