UniProt P25156
Proteasome subunit alpha (P25156)
Proteasome subunit alpha (UniProt P25156), EC 3.4.25.1: 37 experimental structures and 1 predicted model on GenesisL1, 56 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P25156
- Protein
- Proteasome subunit alpha
- EC
- 3.4.25.1
- Experimental structures
- 37
- Predicted models
- 1
- Pockets
- 56 · 3 records with a druggable one
Structures
38 records of P25156 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1PMA | Proteasome from thermoplasma acidophilum | x-ray diffraction | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 1PMA | Proteasome from thermoplasma acidophilum | x-ray diffraction | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 1YA7 | Implications for interactions of proteasome with PAN and PA700 from the 1.9 A structure of a… | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 1YA7 | Implications for interactions of proteasome with pan and PA700 from the 1.9 a structure of a… | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 1YAR | Structure of Archeabacterial 20S proteasome mutant D9S- PA26 complex | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 1YAR | Structure of archeabacterial 20S proteasome mutant D9S- PA26 complex | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 1YAU | Structure of Archeabacterial 20S proteasome- PA26 complex | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 1YAU | Structure of archeabacterial 20S proteasome- PA26 complex | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 2KU1 | Dynamic Regulation of Archaeal Proteasome Gate Opening as Studied by TROSY-NMR | solution nmr | A, B, C, D, E, F, G | — | — |
| 2KU1 | Dynamic regulation of archaeal proteasome gate opening as studied by trosy-NMR | solution nmr | A, B, C, D, E, F, G | — | — |
| 2KU2 | Dynamic Regulation of Archaeal Proteasome Gate Opening as Studied by TROSY-NMR | solution nmr | A, B, C, D, E, F, G | — | — |
| 3C91 | Thermoplasma acidophilum 20S proteasome with an open gate | electron microscopy | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 3C91 | Thermoplasma acidophilum 20S proteasome with an open gate | electron microscopy | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 3C92 | Thermoplasma acidophilum 20S proteasome with a closed gate | electron microscopy | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 3C92 | Thermoplasma acidophilum 20S proteasome with a closed gate | electron microscopy | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 3IPM | Crystal Structure of Archaeal 20S Proteasome in Complex with the C-terminus of PAN | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 3IPM | Crystal structure of archaeal 20S proteasome in complex with the C- terminus of pan | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 3J9I | Thermoplasma acidophilum 20S proteasome | electron microscopy | S, F, T, G, U, A, O, B, P, C, Q, D, R, E | — | — |
| 3J9I | Thermoplasma acidophilum 20S proteasome | electron microscopy | S, F, T, G, U, A, O, B, P, C, Q, D, R, E | — | — |
| 3JRM | Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 3JRM | Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 3JSE | Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 3JSE | Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 3JTL | Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 3JTL | Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator | x-ray diffraction | A, B, C, D, E, F, G | — | — |
| 5VY3 | Thermoplasma acidophilum 20S proteasome using 200KEV with stage position | electron microscopy | A, C, E, G, I, K, M, O, Q, S, U, W, Y, 0 | — | — |
| 5VY4 | Thermoplasma acidophilum 20S Proteasome using 200keV with image shift | electron microscopy | A, C, E, G, I, K, M, O, Q, S, U, W, Y, 0 | — | — |
| 5VY4 | Thermoplasma acidophilum 20S proteasome using 200KEV with image shift | electron microscopy | A, C, E, G, I, K, M, O, Q, S, U, W, Y, 0 | — | — |
| 6BDF | 2.8 a resolution reconstruction of the thermoplasma acidophilum 20S proteasome using cryo-electron… | electron microscopy | A, C, E, G, I, K, M, O, Q, S, U, W, Y, 0 | — | — |
| 6UTF | Allosteric coupling between alpha-rings of the 20S proteasome, archaea 20S proteasome singly capped… | electron microscopy | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 6UTG | Allosteric coupling between alpha-rings of the 20S proteasome, 20S singly capped with a PA26/V230F | electron microscopy | A, B, C, D, E, F, G, a, b, c, d, e, f, g | — | 14 (best 0.83) |
| 6UTG | Allosteric coupling between alpha-rings of the 20S proteasome, 20S singly capped with a PA26/V230F | electron microscopy | A, B, C, D, E, F, G, a, b, c, d, e, f, g | — | — |
| 6UTH | Allosteric coupling between alpha-rings of 20S proteasome, 20S proteasome singly capped with a… | electron microscopy | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 6UTI | Allosteric coupling between alpha-rings of 20S proteasome, 20S proteasome with singly capped pan… | electron microscopy | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 6UTJ | Allosteric couple between alpha rings of the 20S proteasome. 20S proteasome singly capped by… | electron microscopy | A, B, C, D, E, F, G, a, b, c, d, e, f, g | — | — |
| 8F66 | Thermoplasma acidophilum 20S proteasome - L81Y mutation in alpha subunit | electron microscopy | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | 20 (best 0.77) |
| 8F6A | Thermoplasma acidophilum 20S proteasome - wild type | electron microscopy | A, P, B, C, D, E, F, G, O, Q, R, S, T, U | — | 20 (best 0.77) |
| P25156 | AlphaFold monomer V2.0 prediction for proteasome subunit alpha (P25156) | predicted | A | — | 2 (best 0.43) |
Experiment against prediction
- 3JRM chain A against the predicted model P25156: TM-score 0.99, RMSD 0.73 Å
- 3JRM chain A against the predicted model P25156: TM-score 0.99, RMSD 0.73 Å
- 6UTG chain D against the predicted model P25156: TM-score 0.98, RMSD 0.74 Å
- 1YA7 chain A against the predicted model P25156: TM-score 0.98, RMSD 0.75 Å
- 1YA7 chain A against the predicted model P25156: TM-score 0.98, RMSD 0.75 Å
- 6UTG chain F against the predicted model P25156: TM-score 0.98, RMSD 0.74 Å
- 3JSE chain A against the predicted model P25156: TM-score 0.98, RMSD 0.75 Å
- 3JSE chain A against the predicted model P25156: TM-score 0.98, RMSD 0.75 Å
- 6UTG chain G against the predicted model P25156: TM-score 0.98, RMSD 0.75 Å
- 6UTG chain E against the predicted model P25156: TM-score 0.98, RMSD 0.75 Å
Elsewhere
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