Research workbench
Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator
Analyse Crystal structure of archaeal 20S proteasome in complex with mutated P26… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3JTL
- Type
- protein
- Length
- 4,536 residues
- Chains
- 21
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha; Proteasome subunit beta; Proteasome activator protein PA26
- EC
- 3.4.25.1
- UniProt
- P25156, P28061, Q9U8G2
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 48% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Proteasome subunit alpha (EC 3.4.25.1) | protein | 227 | 33% helix, 26% strand | P25156 |
| H, I, J, K, L, M, N | Proteasome subunit beta (EC 3.4.25.1) | protein | 203 | 37% helix, 30% strand | P28061 |
| O, P, Q, R, S, T, U | Proteasome activator protein PA26 | protein | 218 | 73% helix, 1% strand | Q9U8G2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1136 | 0.80 | 0.81 | 136 | empty |
| 2 | 1174 | 0.80 | 0.81 | 139 | empty |
| 3 | 868 | 0.78 | 0.81 | 107 | empty |
| 4 | 864 | 0.76 | 0.80 | 105 | empty |
| 5 | 549 | 0.75 | 0.83 | 81 | empty |
Interfaces
56 interfaces between chains.
- S–T · 2193 Ų buried · 38 hydrogen bonds · protein-protein
- Q–R · 2172 Ų buried · 34 hydrogen bonds · protein-protein
- P–Q · 2172 Ų buried · 34 hydrogen bonds · protein-protein
- O–P · 2171 Ų buried · 34 hydrogen bonds · protein-protein
- R–S · 2160 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 3JTL · Crystal structure of archaeal 20S proteasome in complex with mutated P26 activator · the same entry in another collection · chain U against U, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25156
- Every structure of UniProt P28061
- Every structure of UniProt Q9U8G2
- Elsewhere: RCSB PDB 3JTL · PDBe 3JTL · UniProt P25156 · UniProt P28061 · UniProt Q9U8G2
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