Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 17% strand (DSSP).

Ligands and binding sites

• 10M · decyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 565 Ų buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

• 3IOL · Crystal structure of Glucagon-Like Peptide-1 in complex with the extracellular domain of… · the same entry in another collection · chain A against A, TM-score 1.00
• P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain A against A, TM-score 0.98
• P01275 · AlphaFold monomer V2.0 prediction for pro-glucagon (P01275) · a predicted model of the same protein · chain B against A, TM-score 0.57

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P43220
• Every structure of UniProt P01275
• Elsewhere: RCSB PDB 3IOL · PDBe 3IOL · UniProt P43220 · UniProt P01275