UniProt P01275
Glucagon (P01275)
Glucagon (UniProt P01275): 42 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01275
- Protein
- Glucagon
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 2 records with a druggable one
Structures
43 records of P01275 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BH0 | Structure of a glucagon analog | x-ray diffraction | A | — | — |
| 1BH0 | Structure of a glucagon analog | x-ray diffraction | A | — | — |
| 1D0R | Solution structure of glucagon-like peptide-1-(7-36)-amide in TRIFLUOROETHANOL/WATER | solution nmr | A | — | — |
| 1D0R | Solution structure of glucagon-like peptide-1-(7-36)-amide in TRIFLUOROETHANOL/WATER | solution nmr | A | — | — |
| 1NAU | NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the… | solution nmr | A | — | — |
| 1NAU | NMR solution structure of the glucagon antagonist [DESHIS1, DESPHE6, GLU9]GLUCAGON amide in the… | solution nmr | A | — | — |
| 2L63 | NMR solution structure of GLP-2 in 2,2,2 trifluroethanol | solution nmr | A | — | — |
| 2L63 | NMR solution structure of glp-2 in 2,2,2 trifluroethanol | solution nmr | A | — | — |
| 2L64 | NMR Solution structure of GLP-2 in DHPC micelles | solution nmr | A | — | — |
| 2L64 | NMR solution structure of glp-2 in dhpc micelles | solution nmr | A | — | — |
| 2M5P | Solution structure of lipidated glucagon analog in water | solution nmr | X | — | — |
| 2M5P | Solution structure of lipidated glucagon analog in water | solution nmr | X | — | — |
| 2M5Q | Solution structure of lipidated glucagon analog in d-TFE | solution nmr | X | — | — |
| 2M5Q | Solution structure of lipidated glucagon analog in D-tfe | solution nmr | X | — | — |
| 3IOL | Crystal structure of Glucagon-Like Peptide-1 in complex with the extracellular domain of the… | x-ray diffraction | B | — | — |
| 3IOL | Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the… | x-ray diffraction | B | — | — |
| 4APD | Liraglutide | solution nmr | A | — | — |
| 4APD | LIRAGLUTIDE | solution nmr | A | — | — |
| 5OTU | Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Hcs/Thr11Hcs | x-ray diffraction | B, D | — | — |
| 5OTU | Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8HCS/THR11HCS | x-ray diffraction | B, D | — | — |
| 5OTV | Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8CYC/THR11HCS | x-ray diffraction | D, B | — | — |
| 5OTW | Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8HCS/THR11CYS | x-ray diffraction | D, B | — | — |
| 5OTX | Extracellular domain of GLP-1 receptor in complex with GLP-1 variant Ala8Cys/Thr11Cys | x-ray diffraction | B, D | — | 2 (best 0.41) |
| 5OTX | Extracellular domain of glp-1 receptor in complex with glp-1 variant ALA8CYS/THR11CYS | x-ray diffraction | B, D | — | — |
| 5VAI | Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein | electron microscopy | P | — | 5 (best 0.70) |
| 5VAI | Cryo-EM structure of the activated glucagon-like peptide-1 receptor in complex with G protein | electron microscopy | P | — | — |
| 6EDS | Structure of cysteine-free human insulin-degrading enzyme in complex with glucagon and… | x-ray diffraction | C, D | J22 | — |
| 6LMK | Cryo-EM structure of the human glucagon receptor in complex with gs | electron microscopy | E | — | — |
| 6LML | Cryo-EM structure of the human glucagon receptor in complex with GI1 | electron microscopy | E | — | — |
| 6NZN | Dimer-of-dimer amyloid fibril structure of glucagon | solid-state nmr | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 6PHI | Crystal structure of native glucagon in space group I41 at 1.1 a resolution | x-ray diffraction | A | CL | — |
| 6PHJ | Crystal structure of native glucagon in space group P213 at 1.99 a resolution | x-ray diffraction | A | — | — |
| 6PHK | Crystal structure of glucagon analog with mono-stereoinversion at position 21 (D-ASP21) in space… | x-ray diffraction | A | — | — |
| 6PHL | Crystal structure of glucagon analog with mono-stereoinversion at position 23 (D-Val23) in space… | x-ray diffraction | A | — | — |
| 6PHL | Crystal structure of glucagon analog with mono-stereoinversion at position 23 (D-VAL23) in space… | x-ray diffraction | A | — | — |
| 6PHO | Crystal structure of glucagon analog with selenomethionine substitutions at position 1 and 27 in… | x-ray diffraction | A | — | — |
| 6PHP | Crystal structure of glucagon analog with 4-bromo-phenylalanine substitutions at position 6 and 22… | x-ray diffraction | A | — | — |
| 6VCB | Cryo-EM structure of the glucagon-like peptide-1 receptor in complex with G protein, glp-1 peptide… | electron microscopy | P | QW7 | — |
| 6X18 | Glp-1 peptide hormone bound to glucagon-like peptide-1 (glp-1) receptor | electron microscopy | P | — | — |
| 7D68 | Cryo-EM structure of the human glucagon-like peptide-2 receptor-gs protein complex | electron microscopy | P | — | — |
| 7DUQ | Cryo-EM structure of the compound 2 and glp-1-bound human glp-1 receptor-gs complex | electron microscopy | P | — | — |
| 7XM8 | Glucagon amyloid fibril | electron microscopy | H, G, J, I, K, F, B, A, D, C, E, T, S, V, U, R, N, M, P, O, Q, L | — | 3 (best 0.55) |
| P01275 | AlphaFold monomer V2.0 prediction for pro-glucagon (P01275) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 1 record
- J22 · {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol · in 1 record
- QW7 · 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole · in 1 record
Experiment against prediction
- 7D68 chain P against the predicted model P01275: TM-score 0.83, RMSD 1.81 Å
- 7DUQ chain P against the predicted model P01275: TM-score 0.82, RMSD 1.83 Å
- 6X18 chain P against the predicted model P01275: TM-score 0.80, RMSD 1.47 Å
- 6PHL chain A against the predicted model P01275: TM-score 0.80, RMSD 0.93 Å
- 6PHL chain A against the predicted model P01275: TM-score 0.80, RMSD 0.93 Å
- 6LMK chain E against the predicted model P01275: TM-score 0.79, RMSD 0.58 Å
- 6PHP chain A against the predicted model P01275: TM-score 0.79, RMSD 1.27 Å
- 6PHJ chain A against the predicted model P01275: TM-score 0.78, RMSD 0.76 Å
- 6PHI chain A against the predicted model P01275: TM-score 0.75, RMSD 1.82 Å
- 6LML chain E against the predicted model P01275: TM-score 0.75, RMSD 0.87 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.