MolNFT v1 · #62046 · protein
Structure of porcine pancreatic elastase with the magic triangle I3C
3E3T · Elastase-1: “Structure of porcine pancreatic elastase with the magic triangle I3C”. X-ray diffraction, 4 ligands (I3C, NA, SO4), 2 pockets (best druggability 0.33). MolNFT v1 #62046 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3E3T
- Type
- protein
- Length
- 240 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elastase-1
- EC
- 3.4.21.36
- UniProt
- P00772
- Ligands
- I3C, NA, SO4, IOD
- Pockets
- 2 · best druggability 0.33
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elastase-1 (EC 3.4.21.36) | protein | 240 | 11% helix, 39% strand | P00772 |
Ligands and binding sites
- I3C · 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid · ligand · 4 copies · chains A
- NA · Sodium ion · metal · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- IOD · Iodide ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.33 | 0.74 | 26 | SO4 |
| 2 | 54 | 0.31 | 0.76 | 13 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3E3T · Structure of porcine pancreatic elastase with the magic triangle I3C · the same entry in another collection · chain A against A, TM-score 1.00
- P00772 · AlphaFold monomer V2.0 prediction for chymotrypsin-like elastase family member 1 (P00772) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00772
- Elsewhere: RCSB PDB 3E3T · PDBe 3E3T · UniProt P00772
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