MolNFT v1 · #61409 · protein

Complex between the kinase domain of human ephrin type-a receptor 7 (EPHA7) and inhibitor alw-II-49-7

3DKO: “Complex between the kinase domain of human ephrin type-a receptor 7 (EPHA7) and inhibitor alw-II-49-7”. X-ray diffraction, 1 ligand (IHZ), 1 pocket (best druggability 0.66). MolNFT v1 #61409 on GenesisL1: 3D structure, binding sites…

PDB: 3DKO
Type: protein
Length: 275 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ephrin type-a receptor 7
EC: 2.7.10.1
UniProt: Q15375
Ligands: IHZ
Pockets: 1 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ephrin type-a receptor 7 (EC 2.7.10.1)	protein	275	44% helix, 15% strand	Q15375

Ligands and binding sites

IHZ · 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	314	0.66	0.81	41	IHZ

Compared structures

3DKO · Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
Q15375 · AlphaFold monomer V2.0 prediction for ephrin type-a receptor 7 (Q15375) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15375
Elsewhere: RCSB PDB 3DKO · PDBe 3DKO · UniProt Q15375

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