Research workbench
Complex between the kinase domain of human ephrin type-a receptor 7 (EPHA7) and inhibitor alw-II-49-7
Analyse Complex between the kinase domain of human ephrin type-a receptor 7 (EPHA7) and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DKO
- Type
- protein
- Length
- 275 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ephrin type-a receptor 7
- EC
- 2.7.10.1
- UniProt
- Q15375
- Ligands
- IHZ
- Pockets
- 1 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ephrin type-a receptor 7 (EC 2.7.10.1) | protein | 275 | 44% helix, 15% strand | Q15375 |
Ligands and binding sites
- IHZ · 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 314 | 0.66 | 0.81 | 41 | IHZ |
Compared structures
- 3DKO · Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
- Q15375 · AlphaFold monomer V2.0 prediction for ephrin type-a receptor 7 (Q15375) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15375
- Elsewhere: RCSB PDB 3DKO · PDBe 3DKO · UniProt Q15375
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