UniProt Q15375
Ephrin type-A receptor 7 (Q15375)
Ephrin type-A receptor 7 (UniProt Q15375), EC 2.7.10.1: 12 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15375
- Protein
- Ephrin type-A receptor 7
- EC
- 2.7.10.1
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 3 · 2 records with a druggable one
Structures
13 records of Q15375 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2REI | Kinase domain of human ephrin type-A receptor 7 (Epha7) | x-ray diffraction | A | — | — |
| 2REI | Kinase domain of human ephrin type-a receptor 7 (EPHA7) | x-ray diffraction | A | — | — |
| 3DKO | Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor… | x-ray diffraction | A | — | — |
| 3DKO | Complex between the kinase domain of human ephrin type-a receptor 7 (EPHA7) and inhibitor… | x-ray diffraction | A | — | — |
| 3H8M | SAM domain of human ephrin type-a receptor 7 (EPHA7) | x-ray diffraction | A, B | — | — |
| 3H8M | SAM domain of human ephrin type-a receptor 7 (EPHA7) | x-ray diffraction | A, B | — | — |
| 7EEC | Crystal structure of EphA7 mutant G656R | x-ray diffraction | A | — | 1 (best 0.60) |
| 7EEC | Crystal structure of EPHA7 mutant G656R | x-ray diffraction | A | — | — |
| 7EED | Crystal structure of EphA7 mutant D751H | x-ray diffraction | A | — | 2 (best 0.59) |
| 7EED | Crystal structure of EPHA7 mutant D751H | x-ray diffraction | A | — | — |
| 7EEF | Crystal structure of EphA7 mutant G656E | x-ray diffraction | A | — | — |
| 7EEF | Crystal structure of EPHA7 mutant G656E | x-ray diffraction | A | — | — |
| Q15375 | AlphaFold monomer V2.0 prediction for ephrin type-a receptor 7 (Q15375) | predicted | A | — | — |
Experiment against prediction
- 2REI chain A against the predicted model Q15375: TM-score 0.98, RMSD 0.89 Å
- 2REI chain A against the predicted model Q15375: TM-score 0.98, RMSD 0.89 Å
- 7EEC chain A against the predicted model Q15375: TM-score 0.98, RMSD 0.97 Å
- 7EEC chain A against the predicted model Q15375: TM-score 0.98, RMSD 0.97 Å
- 3DKO chain A against the predicted model Q15375: TM-score 0.98, RMSD 1.08 Å
- 3DKO chain A against the predicted model Q15375: TM-score 0.98, RMSD 1.08 Å
- 7EED chain A against the predicted model Q15375: TM-score 0.97, RMSD 1.10 Å
- 7EED chain A against the predicted model Q15375: TM-score 0.97, RMSD 1.10 Å
- 7EEF chain A against the predicted model Q15375: TM-score 0.97, RMSD 1.18 Å
- 7EEF chain A against the predicted model Q15375: TM-score 0.97, RMSD 1.18 Å
Elsewhere
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