MolNFT v1 · #177306 · protein

Crystal structure of EPHA7 mutant G656R

7EEC · Ephrin type-a receptor 7: “Crystal structure of EPHA7 mutant G656R”. X-ray diffraction, 1 pocket (best druggability 0.60). MolNFT v1 #177306 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EEC
Type: protein
Length: 277 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ephrin type-a receptor 7
EC: 2.7.10.1
UniProt: Q15375
Pockets: 1 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ephrin type-a receptor 7 (EC 2.7.10.1)	protein	277	42% helix, 16% strand	Q15375

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	356	0.60	0.77	44	empty

Compared structures

7EEC · Crystal structure of EphA7 mutant G656R · the same entry in another collection · chain A against A, TM-score 1.00
Q15375 · AlphaFold monomer V2.0 prediction for ephrin type-a receptor 7 (Q15375) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15375
Elsewhere: RCSB PDB 7EEC · PDBe 7EEC · UniProt Q15375

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