MolNFT v1 · #61058 · protein
Structure of the human mdmx protein bound to the P53 tumor suppressor transactivation domain
3DAC · MDM4 protein: “Structure of the human mdmx protein bound to the P53 tumor suppressor transactivation domain”. X-ray diffraction, 1 pocket (best druggability 0.57). MolNFT v1 #61058 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3DAC
- Type
- protein
- Length
- 195 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MDM4 protein; Cellular tumor antigen P53
- UniProt
- Q7ZUW7, P04637
- Pockets
- 1 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M, A | MDM4 protein | protein | 85 | 47% helix, 19% strand | Q7ZUW7 |
| P | Cellular tumor antigen P53 | protein | 12 | 42% helix, 0% strand | P04637 |
| B | Cellular tumor antigen P53 | protein | 13 | 46% helix, 0% strand | P04637 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 262 | 0.57 | 0.77 | 36 | empty |
Interfaces
5 interfaces between chains.
- A–B · 577 Ų buried · 3 hydrogen bonds · protein-protein
- M–P · 522 Ų buried · 4 hydrogen bonds · protein-protein
- M–A · 327 Ų buried · 10 hydrogen bonds · protein-protein
- P–A · 132 Ų buried · 1 hydrogen bond · protein-protein
- M–B · 114 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3DAC · Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation… · the same entry in another collection · chain M against M, TM-score 1.00
- Q7ZUW7 · AlphaFold monomer V2.0 prediction for protein MDM4 (Q7ZUW7) · a predicted model of the same protein · chain M against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7ZUW7
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 3DAC · PDBe 3DAC · UniProt Q7ZUW7 · UniProt P04637
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