Research workbench
Structure of the human mdmx protein bound to the P53 tumor suppressor transactivation domain
Analyse Structure of the human mdmx protein bound to the P53 tumor suppressor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DAC
- Type
- protein
- Length
- 195 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MDM4 protein; Cellular tumor antigen P53
- UniProt
- Q7ZUW7, P04637
- Pockets
- 1 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M, A | MDM4 protein | protein | 85 | 47% helix, 19% strand | Q7ZUW7 |
| P | Cellular tumor antigen P53 | protein | 12 | 42% helix, 0% strand | P04637 |
| B | Cellular tumor antigen P53 | protein | 13 | 46% helix, 0% strand | P04637 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 262 | 0.57 | 0.77 | 36 | empty |
Interfaces
5 interfaces between chains.
- A–B · 577 Ų buried · 3 hydrogen bonds · protein-protein
- M–P · 522 Ų buried · 4 hydrogen bonds · protein-protein
- M–A · 327 Ų buried · 10 hydrogen bonds · protein-protein
- P–A · 132 Ų buried · 1 hydrogen bond · protein-protein
- M–B · 114 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3DAC · Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation… · the same entry in another collection · chain M against M, TM-score 1.00
- Q7ZUW7 · AlphaFold monomer V2.0 prediction for protein MDM4 (Q7ZUW7) · a predicted model of the same protein · chain M against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7ZUW7
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 3DAC · PDBe 3DAC · UniProt Q7ZUW7 · UniProt P04637
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