MolNFT v1 · #60517 · protein
Crystal structure of 2:2:2 FGFR2D2:FGF1:SOS complex
3CU1 · Fibroblast growth factor receptor 2: “Crystal structure of 2:2:2 FGFR2D2:FGF1:SOS complex”. X-ray diffraction, 2 ligands (GU4, YYJ), 2 pockets (best druggability 0.74). MolNFT v1 #60517 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3CU1
- Type
- protein
- Length
- 459 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor receptor 2; Heparin-binding growth factor 1
- EC
- 2.7.10.1
- UniProt
- P21802, P05230
- Ligands
- GU4, YYJ
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 10% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Fibroblast growth factor receptor 2 (EC 2.7.10.1) | protein | 100 | 13% helix, 50% strand | P21802 |
| B | Heparin-binding growth factor 1 | protein | 128 | 9% helix, 39% strand | P05230 |
| D | Heparin-binding growth factor 1 | protein | 131 | 9% helix, 37% strand | P05230 |
Ligands and binding sites
- GU4 · 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose · ligand · 2 copies · chains A, B, C, D
- YYJ · 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose · ligand · 2 copies · chains B, C, D, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1067 | 0.74 | 0.77 | 88 | GU4, YYJ |
| 2 | 80 | 0.31 | 0.73 | 16 | empty |
Interfaces
5 interfaces between chains.
- C–D · 507 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 474 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 291 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 106 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 105 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3CU1 · Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex · the same entry in another collection · chain C against C, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P21802 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 2 (P21802) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21802
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 3CU1 · PDBe 3CU1 · UniProt P21802 · UniProt P05230
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