MolNFT v1 · #56163 · protein

Crystal structure of full-length human RPA14/32 heterodimer

2Z6K · Replication protein a 32 kda subunit: “Crystal structure of full-length human RPA14/32 heterodimer”. X-ray diffraction, 5 pockets (best druggability 0.72). MolNFT v1 #56163 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2Z6K
Type: protein
Length: 487 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Replication protein a 32 kda subunit; Replication protein a 14 kda subunit
UniProt: P15927, P35244
Pockets: 5 · best druggability 0.72

Structure

x-ray diffraction · 3 distinct chains · 19% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Replication protein a 32 kda subunit	protein	127	20% helix, 42% strand	P15927
B	Replication protein a 32 kda subunit	protein	126	19% helix, 37% strand	P15927
C, D	Replication protein a 14 kda subunit	protein	117	19% helix, 34% strand	P35244

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	716	0.72	0.78	55	empty
2	171	0.54	0.79	23	empty
3	113	0.46	0.79	24	empty
4	92	0.44	0.79	19	empty
5	59	0.37	0.79	13	empty

Interfaces

5 interfaces between chains.

A–C · 1334 Å² buried · 15 hydrogen bonds · protein-protein
B–D · 1271 Å² buried · 12 hydrogen bonds · protein-protein
A–D · 279 Å² buried · 1 hydrogen bond · protein-protein
B–C · 278 Å² buried · 1 hydrogen bond · protein-protein
A–B · 254 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2Z6K · Crystal structure of full-length human RPA14/32 heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
P35244 · AlphaFold monomer V2.0 prediction for replication protein a 14 kda subunit (P35244) · a predicted model of the same protein · chain C against A, TM-score 0.98
P15927 · AlphaFold monomer V2.0 prediction for replication protein a 32 kda subunit (P15927) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15927
Every structure of UniProt P35244
Elsewhere: RCSB PDB 2Z6K · PDBe 2Z6K · UniProt P15927 · UniProt P35244

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