Research workbench
Crystal structure of full-length human RPA14/32 heterodimer
Analyse Crystal structure of full-length human RPA14/32 heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Z6K
- Type
- protein
- Length
- 487 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replication protein a 32 kda subunit; Replication protein a 14 kda subunit
- UniProt
- P15927, P35244
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replication protein a 32 kda subunit | protein | 127 | 20% helix, 42% strand | P15927 |
| B | Replication protein a 32 kda subunit | protein | 126 | 19% helix, 37% strand | P15927 |
| C, D | Replication protein a 14 kda subunit | protein | 117 | 19% helix, 34% strand | P35244 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 716 | 0.72 | 0.78 | 55 | empty |
| 2 | 171 | 0.54 | 0.79 | 23 | empty |
| 3 | 113 | 0.46 | 0.79 | 24 | empty |
| 4 | 92 | 0.44 | 0.79 | 19 | empty |
| 5 | 59 | 0.37 | 0.79 | 13 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1334 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 1271 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 279 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 278 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 254 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2Z6K · Crystal structure of full-length human RPA14/32 heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
- P35244 · AlphaFold monomer V2.0 prediction for replication protein a 14 kda subunit (P35244) · a predicted model of the same protein · chain C against A, TM-score 0.98
- P15927 · AlphaFold monomer V2.0 prediction for replication protein a 32 kda subunit (P15927) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15927
- Every structure of UniProt P35244
- Elsewhere: RCSB PDB 2Z6K · PDBe 2Z6K · UniProt P15927 · UniProt P35244
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