MolNFT v1 · #51262 · protein
Myosin VI (md) pre-powerstroke state (MG.ADP.VO4)
2V26: “Myosin VI (md) pre-powerstroke state (MG.ADP.VO4)”. X-ray diffraction, 4 ligands (ADP, MG, SO4), 6 pockets (best druggability 0.77). MolNFT v1 #51262 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2V26
- Type
- protein
- Length
- 747 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin VI
- UniProt
- Q29122
- Ligands
- ADP, MG, SO4, VO4
- Pockets
- 6 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin VI | protein | 747 | 48% helix, 16% strand | Q29122 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- VO4 · Vanadate ion · ion · chains A
- EDO · 1,2-ethanediol · additive · 7 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 850 | 0.77 | 0.80 | 87 | EDO |
| 2 | 480 | 0.74 | 0.83 | 57 | ADP, VO4, MG |
| 3 | 417 | 0.70 | 0.81 | 50 | empty |
| 4 | 233 | 0.66 | 0.83 | 49 | EDO |
| 5 | 89 | 0.40 | 0.77 | 18 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q29122
- Elsewhere: RCSB PDB 2V26 · PDBe 2V26 · UniProt Q29122
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.