MolNFT v1 · #48567 · protein
The intrinsic affinity between E2 and the cys domain of E1 in ubiquitin-like modifications
2PX9 · Sumo-activating enzyme subunit 2: “The intrinsic affinity between E2 and the cys domain of E1 in ubiquitin-like modifications”. Solution nmr, 3 pockets (best druggability 0.74). MolNFT v1 #48567 on GenesisL1: 3D structure, binding…
- PDB
- 2PX9
- Type
- protein
- Length
- 375 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sumo-activating enzyme subunit 2; Sumo-conjugating enzyme UBC9
- EC
- 6.3.2.-
- UniProt
- Q9UBT2, P63279
- Pockets
- 3 · best druggability 0.74
Structure
solution nmr · 2 distinct chains · 42% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sumo-activating enzyme subunit 2 (EC 6.3.2.-) | protein | 217 | 47% helix, 0% strand | Q9UBT2 |
| B | Sumo-conjugating enzyme UBC9 (EC 6.3.2.-) | protein | 158 | 34% helix, 16% strand | P63279 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 843 | 0.74 | 0.78 | 77 | empty |
| 2 | 143 | 0.44 | 0.76 | 26 | empty |
| 3 | 72 | 0.36 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 782 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 2PX9 · The intrinsic affinity between E2 and the Cys domain of E1 in Ubiquitin-like modifications · the same entry in another collection · chain A against A, TM-score 1.00
- P63279 · AlphaFold monomer V2.0 prediction for sumo-conjugating enzyme UBC9 (P63279) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q9UBT2 · AlphaFold monomer V2.0 prediction for sumo-activating enzyme subunit 2 (Q9UBT2) · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBT2
- Every structure of UniProt P63279
- Elsewhere: RCSB PDB 2PX9 · PDBe 2PX9 · UniProt Q9UBT2 · UniProt P63279
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