UniProt P63279
SUMO-conjugating enzyme UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (UniProt P63279), EC 2.3.2.-, 6.3.2.-: 56 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P63279
- Protein
- SUMO-conjugating enzyme UBC9
- EC
- 2.3.2.-, 6.3.2.-
- Experimental structures
- 56
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 15 · 1 record with a druggable one
Structures
57 records of P63279 in the MolNFT archive: 56 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A3S | HUMAN UBC9 | x-ray diffraction | A | — | — |
| 1A3S | HUMAN UBC9 | x-ray diffraction | A | — | — |
| 1KPS | Structural Basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin… | x-ray diffraction | A, C | — | — |
| 1KPS | Structural basis for E2-mediated sumo conjugation revealed by a complex between ubiquitin… | x-ray diffraction | A, C | — | — |
| 1Z5S | Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2 | x-ray diffraction | A | — | — |
| 1Z5S | Crystal structure of a complex between UBC9, sumo-1, RANGAP1 and NUP358/RANBP2 | x-ray diffraction | A | — | — |
| 2GRN | Crystal Structure of human RanGAP1-Ubc9 | x-ray diffraction | A | — | — |
| 2GRN | Crystal structure of human RANGAP1-UBC9 | x-ray diffraction | A | — | — |
| 2GRO | Crystal Structure of human RanGAP1-Ubc9-N85Q | x-ray diffraction | A | — | — |
| 2GRO | Crystal structure of human RANGAP1-UBC9-N85Q | x-ray diffraction | A | — | — |
| 2GRP | Crystal Structure of human RanGAP1-Ubc9-Y87A | x-ray diffraction | A | — | — |
| 2GRP | Crystal structure of human RANGAP1-UBC9-Y87A | x-ray diffraction | A | — | — |
| 2GRQ | Crystal Structure of human RanGAP1-Ubc9-D127A | x-ray diffraction | A | — | — |
| 2GRQ | Crystal structure of human RANGAP1-UBC9-D127A | x-ray diffraction | A | — | — |
| 2GRR | Crystal Structure of human RanGAP1-Ubc9-D127S | x-ray diffraction | A | — | — |
| 2GRR | Crystal structure of human RANGAP1-UBC9-D127S | x-ray diffraction | A | — | — |
| 2O25 | Ubiquitin-Conjugating Enzyme E2-25 kDa Complexed With SUMO-1-Conjugating Enzyme UBC9 | x-ray diffraction | C, D | — | — |
| 2O25 | Ubiquitin-conjugating enzyme E2-25 kda complexed with sumo-1- conjugating enzyme UBC9 | x-ray diffraction | C, D | — | — |
| 2PE6 | Non-covalent complex between human SUMO-1 and human Ubc9 | x-ray diffraction | A | — | — |
| 2PE6 | Non-covalent complex between human sumo-1 and human UBC9 | x-ray diffraction | A | — | — |
| 2PX9 | The intrinsic affinity between E2 and the Cys domain of E1 in Ubiquitin-like modifications | solution nmr | B | — | — |
| 2PX9 | The intrinsic affinity between E2 and the cys domain of E1 in ubiquitin-like modifications | solution nmr | B | — | — |
| 2XWU | Crystal structure of importin 13 - UBC9 complex | x-ray diffraction | A | — | — |
| 2XWU | Crystal structure of importin 13 - UBC9 complex | x-ray diffraction | A | — | — |
| 3A4S | The crystal structure of the SLD2:Ubc9 complex | x-ray diffraction | A, B | — | — |
| 3A4S | The crystal structure of the SLD2:UBC9 complex | x-ray diffraction | A, B | — | — |
| 3UIN | Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 | x-ray diffraction | A | — | — |
| 3UIN | Complex between human RANGAP1-SUMO2, UBC9 and the IR1 domain from RANBP2 | x-ray diffraction | A | — | — |
| 3UIO | Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II | x-ray diffraction | A | — | — |
| 3UIO | Complex between human RANGAP1-SUMO2, UBC9 and the IR1 domain from RANBP2 containing IR2 motif II | x-ray diffraction | A | — | — |
| 3UIP | Complex between human RanGAP1-SUMO1, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II | x-ray diffraction | A | — | — |
| 3UIP | Complex between human RANGAP1-SUMO1, UBC9 and the IR1 domain from RANBP2 containing IR2 motif II | x-ray diffraction | A | — | — |
| 4W5V | Crystal structure of Human SUMO E2-conjugating enzyme (Ubc9) in complex with E1-activating enzyme… | x-ray diffraction | A | — | — |
| 4W5V | Crystal structure of human sumo E2-conjugating enzyme (UBC9) in complex with E1-activating enzyme… | x-ray diffraction | A | — | — |
| 4Y1L | Ubc9 Homodimer The Missing Link in Poly-SUMO Chain Formation | x-ray diffraction | A, B | — | — |
| 4Y1L | UBC9 homodimer the missing link in poly-sumo chain formation | x-ray diffraction | A, B | — | — |
| 5D2M | Complex between human SUMO2-RANGAP1, UBC9 and ZNF451 | x-ray diffraction | A, D | — | — |
| 5F6D | Crystal structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 6 | x-ray diffraction | A | 5VJ | — |
| 5F6D | Crystal structure of UBC9 (K48A/K49A/E54A) complexed with fragment 6 | x-ray diffraction | A | — | — |
| 5F6E | Crystal Structure of human Ubc9 (K48A/K49A/E54A) | x-ray diffraction | A | — | — |
| 5F6E | Crystal structure of human UBC9 (K48A/K49A/E54A) | x-ray diffraction | A | — | — |
| 5F6U | Crystal Structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 8 (JSS190B146) | x-ray diffraction | A | 5VK | — |
| 5F6U | Crystal structure of UBC9 (K48A/K49A/E54A) complexed with fragment 8 (JSS190B146) | x-ray diffraction | A | — | — |
| 5F6V | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol from fragment… | x-ray diffraction | A | 5VL | — |
| 5F6V | Crystal structure of UBC9 (K48/K49A/E54A) complexed with fragment 1 (biphenol from fragment… | x-ray diffraction | A | — | — |
| 5F6W | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol) | x-ray diffraction | A | 5VL | — |
| 5F6W | Crystal structure of UBC9 (K48/K49A/E54A) complexed with fragment 1 (biphenol) | x-ray diffraction | A | — | — |
| 5F6X | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole from… | x-ray diffraction | A | 5VM | — |
| 5F6X | Crystal structure of UBC9 (K48/K49A/E54A) complexed with fragment 2 (mercaptobenzoxazole from… | x-ray diffraction | A | — | — |
| 5F6Y | Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole) | x-ray diffraction | A | 5VM | — |
| 5F6Y | Crystal structure of UBC9 (K48/K49A/E54A) complexed with fragment 2 (mercaptobenzoxazole) | x-ray diffraction | A | — | — |
| 5FQ2 | Crystal structure of human SUMO E1 UFD domain in complex with Ubc9 in a P422 space group. | x-ray diffraction | A | — | — |
| 5FQ2 | Crystal structure of human sumo E1 ufd domain in complex with UBC9 in a P422 space group. | x-ray diffraction | A | — | — |
| 6SYF | Human Ubc9 with covalent isopeptide ligand | x-ray diffraction | A, B, C, D | — | 8 (best 0.43) |
| 6SYF | Human UBC9 with covalent isopeptide ligand | x-ray diffraction | A, B, C, D | ACE | — |
| 9B62 | Human RANBP2/RAN(GTP)/RANGAP1-SUMO1/UBC9/CRM1/RAN(GTP) - composite map and model | electron microscopy | C | — | 7 (best 0.70) |
| P63279 | AlphaFold monomer V2.0 prediction for sumo-conjugating enzyme UBC9 (P63279) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5F6W chain A against the predicted model P63279: TM-score 1.00, RMSD 0.26 Å
- 5F6W chain A against the predicted model P63279: TM-score 1.00, RMSD 0.26 Å
- 5F6V chain A against the predicted model P63279: TM-score 1.00, RMSD 0.27 Å
- 5F6V chain A against the predicted model P63279: TM-score 1.00, RMSD 0.27 Å
- 5F6U chain A against the predicted model P63279: TM-score 1.00, RMSD 0.28 Å
- 5F6U chain A against the predicted model P63279: TM-score 1.00, RMSD 0.28 Å
- 5F6D chain A against the predicted model P63279: TM-score 1.00, RMSD 0.28 Å
- 5F6D chain A against the predicted model P63279: TM-score 1.00, RMSD 0.28 Å
- 5F6E chain A against the predicted model P63279: TM-score 1.00, RMSD 0.29 Å
- 5F6E chain A against the predicted model P63279: TM-score 1.00, RMSD 0.29 Å
Elsewhere
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