UniProt Q9UBT2
SUMO-activating enzyme subunit 2 (Q9UBT2)
SUMO-activating enzyme subunit 2 (UniProt Q9UBT2), EC 2.3.2.-: 20 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9UBT2
- Protein
- SUMO-activating enzyme subunit 2
- EC
- 2.3.2.-
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 12 · 2 records with a druggable one
Structures
21 records of Q9UBT2 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Y8Q | Sumo E1 activating enzyme SAE1-SAE2-mg-ATP complex | x-ray diffraction | B, D | — | — |
| 1Y8Q | Sumo E1 activating enzyme SAE1-SAE2-mg-ATP complex | x-ray diffraction | B, D | — | — |
| 1Y8R | Sumo E1 activating enzyme SAE1-SAE2-SUMO1-mg-ATP complex | x-ray diffraction | B, E | — | — |
| 1Y8R | Sumo E1 activating enzyme SAE1-SAE2-SUMO1-mg-ATP complex | x-ray diffraction | B, E | — | — |
| 2PX9 | The intrinsic affinity between E2 and the Cys domain of E1 in Ubiquitin-like modifications | solution nmr | A | — | — |
| 2PX9 | The intrinsic affinity between E2 and the cys domain of E1 in ubiquitin-like modifications | solution nmr | A | — | — |
| 3KYC | Human SUMO E1 complex with a SUMO1-AMP mimic | x-ray diffraction | B | — | — |
| 3KYC | Human sumo E1 complex with a SUMO1-AMP mimic | x-ray diffraction | B | — | — |
| 3KYD | Human SUMO E1~SUMO1-AMP tetrahedral intermediate mimic | x-ray diffraction | B | — | — |
| 3KYD | Human sumo E1~SUMO1-AMP tetrahedral intermediate mimic | x-ray diffraction | B | — | — |
| 4W5V | Crystal structure of Human SUMO E2-conjugating enzyme (Ubc9) in complex with E1-activating enzyme… | x-ray diffraction | B | — | — |
| 4W5V | Crystal structure of human sumo E2-conjugating enzyme (UBC9) in complex with E1-activating enzyme… | x-ray diffraction | B | — | — |
| 5FQ2 | Crystal structure of human SUMO E1 UFD domain in complex with Ubc9 in a P422 space group. | x-ray diffraction | B | — | — |
| 5FQ2 | Crystal structure of human sumo E1 ufd domain in complex with UBC9 in a P422 space group. | x-ray diffraction | B | — | — |
| 6CWY | Crystal structure of SUMO E1 in complex with an allosteric inhibitor | x-ray diffraction | D | ZN, MG, SO4, FHJ | 8 (best 0.83) |
| 6CWY | Crystal structure of sumo E1 in complex with an allosteric inhibitor | x-ray diffraction | D | ZN, MG, SO4, FHJ | — |
| 6CWZ | Crystal structure of apo sumo E1 | x-ray diffraction | D | ZN | — |
| 6XOG | Structure of SUMO1-ML786519 adduct bound to sae | x-ray diffraction | B | SO4, ZN, VAY | — |
| 6XOH | Structure of SUMO1-ML00789344 adduct bound to sae | x-ray diffraction | B | SO4, ZN, VB7 | — |
| 6XOI | Structure of SUMO1-ML00752641 adduct bound to sae | x-ray diffraction | B | SO4, ZN, VBA | — |
| Q9UBT2 | AlphaFold monomer V2.0 prediction for sumo-activating enzyme subunit 2 (Q9UBT2) | predicted | A | — | 4 (best 0.73) |
Ligands
- ZN · Zinc ion · in 6 records
- SO4 · Sulfate ion · in 5 records
- FHJ · dimethyl (1S,2S,3R,4R)-1-[(1S)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate · in 2 records
- MG · Magnesium ion · in 2 records
- VAY · {(1R,2R,3S,4R)-4-[(5-{4-[(1S)-1-(6-bromopyridin-2-yl)-1-hydroxyethyl]thiophene-2-carbonyl}pyrimidin-4-yl) amino]-2,3-dihydroxycyclopentyl}methyl sulfamate · in 1 record
- VB7 · {(1R,2S,4R)-4-[(5-{4-[(1R)-3,4-dihydro-1H-2-benzopyran-1-yl]thiophene-2-carbonyl}pyrimidin-4-yl)amino]-2-hydroxycyclopentyl}methyl sulfamate · in 1 record
- VBA · [(1R,2R,3S,4R)-4-{[5-(1-benzyl-1H-pyrazole-3-carbonyl) pyrimidin-4-yl]amino}-2,3-dihydroxycyclopentyl]methyl sulfamate · in 1 record
Experiment against prediction
- 6XOI chain B against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.60 Å
- 6XOH chain B against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.70 Å
- 1Y8Q chain D against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.75 Å
- 1Y8Q chain D against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.75 Å
- 6CWZ chain D against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.74 Å
- 3KYC chain B against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.82 Å
- 3KYC chain B against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.82 Å
- 1Y8R chain E against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.98 Å
- 1Y8R chain E against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.98 Å
- 1Y8Q chain B against the predicted model Q9UBT2: TM-score 0.99, RMSD 0.99 Å
Elsewhere
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