MolNFT v1 · #46257 · protein
Crystal structure of potassium channel KV4.3 in complex with its regulatory subunit KCHIP1 (casp target)
2NZ0 · Kv channel-interacting protein 1: “Crystal structure of potassium channel KV4.3 in complex with its regulatory subunit KCHIP1 (casp target)”. X-ray diffraction, 2 ligands (CA, ZN), 11 pockets (best druggability 0.74). MolNFT v1…
- PDB
- 2NZ0
- Type
- protein
- Length
- 612 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kv channel-interacting protein 1; Potassium voltage-gated channel subfamily D member 3
- UniProt
- Q9NZI2, Q9UK17
- Ligands
- CA, ZN
- Pockets
- 11 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Kv channel-interacting protein 1 | protein | 170 | 59% helix, 2% strand | Q9NZI2 |
| B, D | Potassium voltage-gated channel subfamily D member 3 | protein | 136 | 39% helix, 15% strand | Q9UK17 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 125 | 0.74 | 0.93 | 32 | empty |
| 2 | 616 | 0.72 | 0.80 | 61 | empty |
| 3 | 563 | 0.65 | 0.76 | 55 | empty |
| 4 | 181 | 0.61 | 0.83 | 30 | empty |
| 5 | 93 | 0.56 | 0.85 | 21 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1571 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1421 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 927 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 579 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2NZ0 · Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NZI2 · AlphaFold monomer V2.0 prediction for kv channel-interacting protein 1 (Q9NZI2) · a predicted model of the same protein · chain A against A, TM-score 0.84
- Q9UK17 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily D member… · a predicted model of the same protein · chain B against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZI2
- Every structure of UniProt Q9UK17
- Elsewhere: RCSB PDB 2NZ0 · PDBe 2NZ0 · UniProt Q9NZI2 · UniProt Q9UK17
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