Research workbench
Crystal structure of potassium channel KV4.3 in complex with its regulatory subunit KCHIP1 (casp target)
Analyse Crystal structure of potassium channel KV4.3 in complex with its regulatory… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2NZ0
- Type
- protein
- Length
- 612 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kv channel-interacting protein 1; Potassium voltage-gated channel subfamily D member 3
- UniProt
- Q9NZI2, Q9UK17
- Ligands
- CA, ZN
- Pockets
- 11 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Kv channel-interacting protein 1 | protein | 170 | 59% helix, 2% strand | Q9NZI2 |
| B, D | Potassium voltage-gated channel subfamily D member 3 | protein | 136 | 39% helix, 15% strand | Q9UK17 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 125 | 0.74 | 0.93 | 32 | empty |
| 2 | 616 | 0.72 | 0.80 | 61 | empty |
| 3 | 563 | 0.65 | 0.76 | 55 | empty |
| 4 | 181 | 0.61 | 0.83 | 30 | empty |
| 5 | 93 | 0.56 | 0.85 | 21 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1571 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1421 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 927 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 579 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2NZ0 · Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NZI2 · AlphaFold monomer V2.0 prediction for kv channel-interacting protein 1 (Q9NZI2) · a predicted model of the same protein · chain A against A, TM-score 0.84
- Q9UK17 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily D member… · a predicted model of the same protein · chain B against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZI2
- Every structure of UniProt Q9UK17
- Elsewhere: RCSB PDB 2NZ0 · PDBe 2NZ0 · UniProt Q9NZI2 · UniProt Q9UK17
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