MolNFT v1 · #45736 · protein
Solution structure of the RPN1 T1 site with the RAD23 ubl domain
2NBW · 26S proteasome regulatory subunit RPN1: “Solution structure of the RPN1 T1 site with the RAD23 ubl domain”. Solution nmr, 3 pockets (best druggability 0.70). MolNFT v1 #45736 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2NBW
- Type
- protein
- Length
- 209 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26S proteasome regulatory subunit RPN1; UV excision repair protein RAD23
- UniProt
- P38764, P32628
- Pockets
- 3 · best druggability 0.70
Structure
solution nmr · 2 distinct chains · 46% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome regulatory subunit RPN1 | protein | 131 | 61% helix, 0% strand | P38764 |
| B | UV excision repair protein RAD23 | protein | 78 | 21% helix, 28% strand | P32628 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.70 | 0.85 | 45 | empty |
| 2 | 128 | 0.50 | 0.79 | 25 | empty |
| 3 | 58 | 0.31 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 784 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2NBW · Solution structure of the Rpn1 T1 site with the Rad23 UBL domain · the same entry in another collection · chain A against A, TM-score 1.00
- P32628 · AlphaFold monomer V2.0 prediction for UV excision repair protein RAD23 (P32628) · a predicted model of the same protein · chain B against A, TM-score 0.91
- P38764 · AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN1 (P38764) · a predicted model of the same protein · chain A against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38764
- Every structure of UniProt P32628
- Elsewhere: RCSB PDB 2NBW · PDBe 2NBW · UniProt P38764 · UniProt P32628
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