UniProt P38764
26S proteasome regulatory subunit RPN1 (P38764)
26S proteasome regulatory subunit RPN1 (UniProt P38764): 43 experimental structures and 1 predicted model on GenesisL1, 52 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P38764
- Protein
- 26S proteasome regulatory subunit RPN1
- Experimental structures
- 43
- Predicted models
- 1
- Pockets
- 52 · 15 records with a druggable one
Structures
44 records of P38764 in the MolNFT archive: 43 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N3T | Solution structure of the Rpn1 substrate receptor site toroid 1 (T1) | solution nmr | A | — | — |
| 2N3T | Solution structure of the RPN1 substrate receptor site toroid 1 (T1) | solution nmr | A | — | — |
| 2N3U | Solution structure of the Rpn1 T1 site engaging two monoubiquitin molecules | solution nmr | A | — | — |
| 2N3U | Solution structure of the RPN1 T1 site engaging two monoubiquitin molecules | solution nmr | A | — | — |
| 2N3V | Solution structure of the Rpn1 T1 site with K48-linked diubiquitin in the extended binding mode | solution nmr | A | — | — |
| 2N3V | Solution structure of the RPN1 T1 site with K48-linked diubiquitin in the extended binding mode | solution nmr | A | — | — |
| 2N3W | Solution structure of the Rpn1 T1 site with K48-linked diubiquitin in the contracted binding mode | solution nmr | A | — | — |
| 2N3W | Solution structure of the RPN1 T1 site with K48-linked diubiquitin in the contracted binding mode | solution nmr | A | — | — |
| 2NBW | Solution structure of the Rpn1 T1 site with the Rad23 UBL domain | solution nmr | A | — | — |
| 2NBW | Solution structure of the RPN1 T1 site with the RAD23 ubl domain | solution nmr | A | — | — |
| 3JCO | Structure of yeast 26S proteasome in M1 state derived from Titan dataset | electron microscopy | Z | — | — |
| 3JCP | Structure of yeast 26S proteasome in M2 state derived from Titan dataset | electron microscopy | Z | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Z | — | — |
| 4CR2 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Z | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Z | — | — |
| 4CR3 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Z | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Z | — | — |
| 4CR4 | Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S… | electron microscopy | Z | — | — |
| 5A5B | Structure of the 26S proteasome-Ubp6 complex | electron microscopy | Z | — | — |
| 5A5B | Structure of the 26S proteasome-UBP6 complex | electron microscopy | Z | — | — |
| 5MPB | 26S proteasome in presence of AMP-PNP (s3) | electron microscopy | Z | — | 2 (best 0.78) |
| 5MPC | 26S proteasome in presence of BeFx (s4) | electron microscopy | Z | — | — |
| 5MPD | 26S proteasome in presence of ATP (s1) | electron microscopy | Z | — | 5 (best 0.82) |
| 5MPD | 26S proteasome in presence of ATP (S1) | electron microscopy | Z | — | — |
| 5MPE | 26S proteasome in presence of ATP (s2) | electron microscopy | Z | — | — |
| 5MPE | 26S proteasome in presence of ATP (S2) | electron microscopy | Z | — | — |
| 5WVI | The resting state of yeast proteasome | electron microscopy | Z | — | — |
| 5WVK | Yeast proteasome-ADP-AlFx | electron microscopy | Z | — | 2 (best 0.85) |
| 6FVT | 26S proteasome, s1 state | electron microscopy | Z | — | — |
| 6FVU | 26S proteasome, s2 state | electron microscopy | Z | — | 3 (best 0.82) |
| 6FVV | 26S proteasome, s3 state | electron microscopy | Z | — | 3 (best 0.82) |
| 6FVW | 26S proteasome, s4 state | electron microscopy | Z | — | 3 (best 0.83) |
| 6FVX | 26S proteasome, s5 state | electron microscopy | Z | — | 3 (best 0.83) |
| 6FVY | 26S proteasome, s6 state | electron microscopy | Z | — | 3 (best 0.78) |
| 6J2C | Yeast proteasome in translocation competent state (C3-a) | electron microscopy | Z | — | 2 (best 0.88) |
| 6J2N | yeast proteasome in substrate-processing state (C3-b) | electron microscopy | Z | — | 2 (best 0.86) |
| 6J2X | Yeast proteasome in resting state (C1-a) | electron microscopy | Z | — | — |
| 7QO3 | Structure of the 26S proteasome-Ubp6 complex in the si state (Core Particle and Lid) | electron microscopy | Z | — | 1 (best 0.83) |
| 7QO3 | Structure of the 26S proteasome-UBP6 complex in the si state (core particle and lid) | electron microscopy | Z | — | — |
| 7QO4 | 26S proteasome WT-Ubp6-UbVS complex in the si state (ATPases, Rpn1, Ubp6, and UbVS) | electron microscopy | Z | — | 6 (best 0.82) |
| 7QO4 | 26S proteasome wt-UBP6-ubvs complex in the si state (atpases, RPN1, UBP6, and ubvs) | electron microscopy | Z | — | — |
| 7QO5 | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state | electron microscopy | Z | — | 3 (best 0.83) |
| 7QO6 | 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the s2 state | electron microscopy | Z | — | 4 (best 0.83) |
| P38764 | AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN1 (P38764) | predicted | A | — | 10 (best 0.83) |
Experiment against prediction
- 4CR2 chain Z against the predicted model P38764: TM-score 0.89, RMSD 3.06 Å
- 4CR2 chain Z against the predicted model P38764: TM-score 0.89, RMSD 3.06 Å
- 6J2X chain Z against the predicted model P38764: TM-score 0.87, RMSD 3.48 Å
- 5WVI chain Z against the predicted model P38764: TM-score 0.86, RMSD 3.58 Å
- 7QO4 chain Z against the predicted model P38764: TM-score 0.83, RMSD 3.37 Å
- 7QO4 chain Z against the predicted model P38764: TM-score 0.83, RMSD 3.37 Å
- 7QO3 chain Z against the predicted model P38764: TM-score 0.83, RMSD 3.37 Å
- 7QO3 chain Z against the predicted model P38764: TM-score 0.83, RMSD 3.37 Å
- 7QO5 chain Z against the predicted model P38764: TM-score 0.83, RMSD 3.44 Å
- 5A5B chain Z against the predicted model P38764: TM-score 0.83, RMSD 4.20 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.