MolNFT v1 · #385794 · protein
AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN1 (P38764)
P38764: “AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN1 (P38764)”. 10 pockets (best druggability 0.83). MolNFT v1 #385794 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P38764
- Type
- protein
- Length
- 993 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xdCe7F91edCFe217DdEaC9d1837C7025e0088702f
- Molecule
- 26S proteasome regulatory subunit RPN1
- UniProt
- P38764
- Pockets
- 10 · best druggability 0.83
Structure
1 distinct chain · 53% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome regulatory subunit RPN1 | protein | 993 | 53% helix, 5% strand | P38764 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1064 | 0.83 | 0.84 | 113 | empty |
| 2 | 262 | 0.82 | 0.94 | 38 | empty |
| 3 | 141 | 0.59 | 0.83 | 25 | empty |
| 4 | 181 | 0.53 | 0.78 | 22 | empty |
| 5 | 155 | 0.51 | 0.79 | 28 | empty |
Compared structures
- 7QO4 · 26S proteasome wt-UBP6-ubvs complex in the si state (atpases, RPN1, UBP6, and ubvs) · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 7QO4 · 26S proteasome WT-Ubp6-UbVS complex in the si state (ATPases, Rpn1, Ubp6, and UbVS) · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 7QO3 · Structure of the 26S proteasome-Ubp6 complex in the si state (Core Particle and Lid) · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 7QO3 · Structure of the 26S proteasome-UBP6 complex in the si state (core particle and lid) · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 7QO5 · 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the si state · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 5MPD · 26S proteasome in presence of ATP (S1) · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 5MPD · 26S proteasome in presence of ATP (s1) · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 6FVW · 26S proteasome, s4 state · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 6FVX · 26S proteasome, s5 state · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 7QO6 · 26S proteasome Rpt1-RK -Ubp6-UbVS complex in the s2 state · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 6FVU · 26S proteasome, s2 state · an experimental structure of the same protein · chain A against Z, TM-score 0.76
- 6FVV · 26S proteasome, s3 state · an experimental structure of the same protein · chain A against Z, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38764
- Elsewhere: UniProt P38764 · AlphaFold DB P38764
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