Research workbench
Solution structure of the RPN1 T1 site with the RAD23 ubl domain
Analyse Solution structure of the RPN1 T1 site with the RAD23 ubl domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2NBW
- Type
- protein
- Length
- 209 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26S proteasome regulatory subunit RPN1; UV excision repair protein RAD23
- UniProt
- P38764, P32628
- Pockets
- 3 · best druggability 0.70
Structure
solution nmr · 2 distinct chains · 46% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome regulatory subunit RPN1 | protein | 131 | 61% helix, 0% strand | P38764 |
| B | UV excision repair protein RAD23 | protein | 78 | 21% helix, 28% strand | P32628 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.70 | 0.85 | 45 | empty |
| 2 | 128 | 0.50 | 0.79 | 25 | empty |
| 3 | 58 | 0.31 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 784 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2NBW · Solution structure of the Rpn1 T1 site with the Rad23 UBL domain · the same entry in another collection · chain A against A, TM-score 1.00
- P32628 · AlphaFold monomer V2.0 prediction for UV excision repair protein RAD23 (P32628) · a predicted model of the same protein · chain B against A, TM-score 0.91
- P38764 · AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN1 (P38764) · a predicted model of the same protein · chain A against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38764
- Every structure of UniProt P32628
- Elsewhere: RCSB PDB 2NBW · PDBe 2NBW · UniProt P38764 · UniProt P32628
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.