MolNFT v1 · #43180 · protein
Structural basis for recognition of centromere specific histone H3 variant by nonhistone SCM3
2L5A · Histone H3-like centromeric protein CSE4, protein SCM3…: “Structural basis for recognition of centromere specific histone H3 variant by nonhistone SCM3”. Solution nmr, 4 pockets (best druggability 0.72). MolNFT v1 #43180 on…
- PDB
- 2L5A
- Type
- protein
- Length
- 225 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3-like centromeric protein CSE4, protein SCM3, histone H4
- UniProt
- P36012, Q12334, P02309
- Pockets
- 4 · best druggability 0.72
Structure
solution nmr · 1 distinct chain · 56% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone H3-like centromeric protein CSE4, protein SCM3, histone H4 | protein | 225 | 56% helix, 0% strand | P36012, Q12334, P02309 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.72 | 0.93 | 28 | empty |
| 2 | 146 | 0.64 | 0.86 | 23 | empty |
| 3 | 290 | 0.63 | 0.80 | 27 | empty |
| 4 | 102 | 0.34 | 0.73 | 19 | empty |
Compared structures
- 2L5A · Structural basis for recognition of centromere specific histone H3 variant by nonhistone… · the same entry in another collection · chain A against A, TM-score 1.00
- P36012 · AlphaFold monomer V2.0 prediction for histone H3-like centromeric protein CSE4 (P36012) · a predicted model of the same protein · chain A against A, TM-score 0.29
- P02309 · AlphaFold monomer V2.0 prediction for histone H4 (P02309) · a predicted model of the same protein · chain A against A, TM-score 0.27
- Q12334 · AlphaFold monomer V2.0 prediction for protein SCM3 (Q12334) · a predicted model of the same protein · chain A against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36012
- Every structure of UniProt Q12334
- Every structure of UniProt P02309
- Elsewhere: RCSB PDB 2L5A · PDBe 2L5A · UniProt P36012 · UniProt Q12334 · UniProt P02309
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