UniProt P02309
Histone H4 (P02309)
Histone H4 (UniProt P02309): 71 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 102 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02309
- Protein
- Histone H4
- Experimental structures
- 71
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 102 · 20 records with a druggable one
Structures
72 records of P02309 in the MolNFT archive: 71 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1E6I | Bromodomain from GCN5 complexed with acetylated H4 peptide | x-ray diffraction | P | — | — |
| 1E6I | Bromodomain from GCN5 complexed with acetylated H4 peptide | x-ray diffraction | P | — | — |
| 1ID3 | Crystal structure of the yeast nucleosome core particle reveals fundamental differences in… | x-ray diffraction | B, F | — | — |
| 1ID3 | Crystal structure of the yeast nucleosome core particle reveals fundamental differences in… | x-ray diffraction | B, F | — | — |
| 1Q1A | Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and… | x-ray diffraction | B | — | — |
| 1Q1A | Structure of the yeast HST2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and… | x-ray diffraction | B | — | — |
| 1SZC | Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2… | x-ray diffraction | B | — | — |
| 1SZC | Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent SIR2… | x-ray diffraction | B | — | — |
| 1SZD | Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2… | x-ray diffraction | B | — | — |
| 1SZD | Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent SIR2… | x-ray diffraction | B | — | — |
| 2E3K | Crystal structure of the human Brd2 second bromodomain in complexed with the acetylated histone H4… | x-ray diffraction | Q, R | — | — |
| 2E3K | Crystal structure of the human BRD2 second bromodomain in complexed with the acetylated histone H4… | x-ray diffraction | Q, R | — | — |
| 2H2H | The Structural basis of sirtuin substrate specificity | x-ray diffraction | B | — | — |
| 2H2H | The structural basis of sirtuin substrate specificity | x-ray diffraction | B | — | — |
| 2L5A | Structural basis for recognition of centromere specific histone H3 variant by nonhistone Scm3 | solution nmr | A | — | — |
| 2L5A | Structural basis for recognition of centromere specific histone H3 variant by nonhistone SCM3 | solution nmr | A | — | — |
| 2QQF | Hst2 bound to ADP-HPD and Acetylated histone H4 | x-ray diffraction | B | — | — |
| 2QQF | HST2 bound to ADP-hpd and acetylated histone H4 | x-ray diffraction | B | — | — |
| 2QQG | Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide | x-ray diffraction | B | — | — |
| 2QQG | HST2 bound to ADP-hpd, acetyllated histone H4 and nicotinamide | x-ray diffraction | B | — | — |
| 3TO6 | Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor | x-ray diffraction | B | — | — |
| 3TO6 | Crystal structure of yeast ESA1 hat domain complexed with H4K16COA bisubstrate inhibitor | x-ray diffraction | B | — | — |
| 4JJN | Crystal structure of heterochromatin protein Sir3 in complex with a silenced yeast nucleosome | x-ray diffraction | B, F | — | — |
| 4JJN | Crystal structure of heterochromatin protein SIR3 in complex with a silenced yeast nucleosome | x-ray diffraction | B, F | — | — |
| 4KUD | Crystal structure of N-terminal acetylated Sir3 BAH domain D205N mutant in complex with yeast… | x-ray diffraction | B, F | — | — |
| 4KUD | Crystal structure of N-terminal acetylated SIR3 bah domain D205N mutant in complex with yeast… | x-ray diffraction | B, F | — | — |
| 4PSX | Crystal structure of histone acetyltransferase complex | x-ray diffraction | C, F | — | — |
| 4PSX | Crystal structure of histone acetyltransferase complex | x-ray diffraction | C, F | — | — |
| 4TWI | The structure of Sir2Af1 bound to a succinylated histone peptide | x-ray diffraction | B | — | — |
| 4TWI | The structure of SIR2AF1 bound to a succinylated histone peptide | x-ray diffraction | B | — | — |
| 4TWJ | The structure of Sir2Af2 bound to a myristoylated histone peptide | x-ray diffraction | B | — | — |
| 4TWJ | The structure of SIR2AF2 bound to a myristoylated histone peptide | x-ray diffraction | B | — | — |
| 5ZBA | Crystal structure of RTT109-ASF1-H3-H4-CoA complex | x-ray diffraction | D | IOD | — |
| 5ZBB | Crystal structure of RTT109-ASF1-H3-H4 complex | x-ray diffraction | D | IOD | — |
| 6GEJ | Chromatin remodeller-nucleosome complex at 3.6 A resolution. | electron microscopy | C, D | — | 1 (best 0.80) |
| 6GEJ | Chromatin remodeller-nucleosome complex at 3.6 a resolution. | electron microscopy | C, D | — | — |
| 6GEN | Chromatin remodeller-nucleosome complex at 4.5 A resolution. | electron microscopy | C, D | — | 2 (best 0.80) |
| 6GEN | Chromatin remodeller-nucleosome complex at 4.5 a resolution. | electron microscopy | C, D | — | — |
| 6QLD | Structure of inner kinetochore CCAN-Cenp-A complex | electron microscopy | b, f | — | — |
| 6QLD | Structure of inner kinetochore ccan-cenp-a complex | electron microscopy | b, f | — | — |
| 6RXJ | Crystal structure of CobB wt in complex with H4K16-Acetyl peptide | x-ray diffraction | C, D | — | — |
| 6RXJ | Crystal structure of cobb wt in complex with H4K16-acetyl peptide | x-ray diffraction | C, D | — | — |
| 6RXK | Crystal structure of CobB wt in complex with H4K16-Butyryl peptide | x-ray diffraction | B | — | 2 (best 0.69) |
| 6RXK | Crystal structure of cobb wt in complex with H4K16-butyryl peptide | x-ray diffraction | B | — | — |
| 6RXL | Crystal structure of CobB wt in complex with H4K16-Crotonyl peptide | x-ray diffraction | B | — | 1 (best 0.70) |
| 6RXL | Crystal structure of cobb wt in complex with H4K16-crotonyl peptide | x-ray diffraction | B | — | — |
| 6RXM | Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16-Acetyl peptide | x-ray diffraction | G, H, I, J, K, L | — | 12 (best 0.82) |
| 6RXM | Crystal structure of cobb AC2 (A76G, I131C, V162G) in complex with H4K16-acetyl peptide | x-ray diffraction | G, H, I, J, K, L | — | — |
| 6RXO | Crystal structure of cobb AC2 (A76G, I131C, V162A) in complex with H4K16-buturyl peptide | x-ray diffraction | C, D | — | — |
| 6RXP | Crystal structure of CobB Ac2 (A76G,I131C,V162A) in complex with H4K16-Crotonyl peptide | x-ray diffraction | C, D | — | 5 (best 0.74) |
| 6RXP | Crystal structure of cobb AC2 (A76G,I131C,V162A) in complex with H4K16-crotonyl peptide | x-ray diffraction | C, D | — | — |
| 6RXQ | Crystal structure of CobB Ac2 (A76G,I131C,V162A) in complex with H4K16Cr-2'OH-ADPr peptide… | x-ray diffraction | E, F, G, H | KMQ | 8 (best 0.81) |
| 6RXQ | Crystal structure of cobb AC2 (A76G,I131C,V162A) in complex with H4K16CR-2'OH-adpr peptide… | x-ray diffraction | E, F, G, H | KMQ | — |
| 6RXR | Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16Cr-2'OH-ADPr peptide… | x-ray diffraction | E, F, G, H | KMQ | 7 (best 0.81) |
| 6RXR | Crystal structure of cobb AC2 (A76G, I131C, V162G) in complex with H4K16CR-2'OH-adpr peptide… | x-ray diffraction | E, F, G, H | KMQ | — |
| 7E9C | Cryo-EM structure of the 1:1 Orc1 BAH domain in complex with nucleosome | electron microscopy | B, F | — | 14 (best 0.83) |
| 7K78 | antibody and nucleosome complex | electron microscopy | B, F | — | 10 (best 0.73) |
| 7K78 | Antibody and nucleosome complex | electron microscopy | B, F | — | — |
| 7K7G | nucleosome and Gal4 complex | electron microscopy | B, F | — | 12 (best 0.75) |
| 7K7G | Nucleosome and GAL4 complex | electron microscopy | B, F | — | — |
12 records more on the page itself.
Ligands
Experiment against prediction
- 8OW0 chain f against the predicted model P02309: TM-score 0.95, RMSD 1.03 Å
- 8OW1 chain b against the predicted model P02309: TM-score 0.94, RMSD 0.90 Å
- 7K78 chain B against the predicted model P02309: TM-score 0.94, RMSD 1.09 Å
- 7K78 chain B against the predicted model P02309: TM-score 0.94, RMSD 1.09 Å
- 6QLD chain f against the predicted model P02309: TM-score 0.94, RMSD 1.13 Å
- 8OW1 chain f against the predicted model P02309: TM-score 0.94, RMSD 0.98 Å
- 7K78 chain F against the predicted model P02309: TM-score 0.94, RMSD 1.34 Å
- 7K78 chain F against the predicted model P02309: TM-score 0.94, RMSD 1.34 Å
- 6GEJ chain D against the predicted model P02309: TM-score 0.93, RMSD 0.84 Å
- 6GEJ chain D against the predicted model P02309: TM-score 0.93, RMSD 0.84 Å
Elsewhere
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