Research workbench
Structural basis for recognition of centromere specific histone H3 variant by nonhistone SCM3
Analyse Structural basis for recognition of centromere specific histone H3 variant by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2L5A
- Type
- protein
- Length
- 225 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3-like centromeric protein CSE4, protein SCM3, histone H4
- UniProt
- P36012, Q12334, P02309
- Pockets
- 4 · best druggability 0.72
Structure
solution nmr · 1 distinct chain · 56% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone H3-like centromeric protein CSE4, protein SCM3, histone H4 | protein | 225 | 56% helix, 0% strand | P36012, Q12334, P02309 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.72 | 0.93 | 28 | empty |
| 2 | 146 | 0.64 | 0.86 | 23 | empty |
| 3 | 290 | 0.63 | 0.80 | 27 | empty |
| 4 | 102 | 0.34 | 0.73 | 19 | empty |
Compared structures
- 2L5A · Structural basis for recognition of centromere specific histone H3 variant by nonhistone… · the same entry in another collection · chain A against A, TM-score 1.00
- P36012 · AlphaFold monomer V2.0 prediction for histone H3-like centromeric protein CSE4 (P36012) · a predicted model of the same protein · chain A against A, TM-score 0.29
- P02309 · AlphaFold monomer V2.0 prediction for histone H4 (P02309) · a predicted model of the same protein · chain A against A, TM-score 0.27
- Q12334 · AlphaFold monomer V2.0 prediction for protein SCM3 (Q12334) · a predicted model of the same protein · chain A against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36012
- Every structure of UniProt Q12334
- Every structure of UniProt P02309
- Elsewhere: RCSB PDB 2L5A · PDBe 2L5A · UniProt P36012 · UniProt Q12334 · UniProt P02309
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