Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7

Structure

solution nmr · 2 distinct chains · 53% helix, 4% strand (DSSP).

Ligands and binding sites

• WW7 · N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide · ligand · chains C, I
• CA · Calcium ion · metal · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• C–I · 570 Ų buried · 3 hydrogen bonds · protein-protein

Compared structures

• 2KRD · Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with… · the same entry in another collection · chain C against C, TM-score 1.00
• P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain C against A, TM-score 0.66
• P19429 · AlphaFold monomer V2.0 prediction for troponin I, cardiac muscle (P19429) · a predicted model of the same protein · chain I against A, TM-score 0.30

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63316
• Every structure of UniProt P19429
• Elsewhere: RCSB PDB 2KRD · PDBe 2KRD · UniProt P63316 · UniProt P19429