MolNFT v1 · #38053 · protein
Crystal structure of a beta-CATENIN/BCL9/TCF4 complex
2GL7: “Crystal structure of a beta-CATENIN/BCL9/TCF4 complex”. X-ray diffraction, 7 pockets (best druggability 0.56). MolNFT v1 #38053 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2GL7
- Type
- protein
- Length
- 1,116 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-catenin; Transcription factor 7-like 2; B-cell lymphoma 9 protein
- UniProt
- P35222, Q9NQB0, O00512
- Pockets
- 7 · best druggability 0.56
Structure
x-ray diffraction · 6 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-catenin | protein | 512 | 76% helix, 0% strand | P35222 |
| B | Transcription factor 7-like 2 | protein | 30 | 33% helix, 0% strand | Q9NQB0 |
| C | B-cell lymphoma 9 protein | protein | 23 | 91% helix, 0% strand | O00512 |
| D | Beta-catenin | protein | 506 | 76% helix, 0% strand | P35222 |
| E | Transcription factor 7-like 2 | protein | 28 | 29% helix, 0% strand | Q9NQB0 |
| F | B-cell lymphoma 9 protein | protein | 17 | 88% helix, 0% strand | O00512 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 286 | 0.56 | 0.77 | 37 | empty |
| 2 | 162 | 0.53 | 0.80 | 30 | empty |
| 3 | 167 | 0.51 | 0.78 | 31 | empty |
| 4 | 62 | 0.35 | 0.78 | 13 | empty |
| 5 | 79 | 0.34 | 0.75 | 16 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1781 Ų buried · 20 hydrogen bonds · protein-protein
- D–E · 1699 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 626 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 546 Ų buried · 1 hydrogen bond · protein-protein
- D–F · 412 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2GL7 · Crystal Structure of a beta-catenin/BCL9/Tcf4 complex · the same entry in another collection · chain F against F, TM-score 1.00
- P35222 · AlphaFold monomer V2.0 prediction for catenin beta-1 (P35222) · a predicted model of the same protein · chain D against A, TM-score 0.99
- O00512 · AlphaFold monomer V2.0 prediction for B-cell CLL/LYMPHOMA 9 protein (O00512) · a predicted model of the same protein · chain C against A, TM-score 0.72
- Q9NQB0 · AlphaFold monomer V2.0 prediction for transcription factor 7-like 2 (Q9NQB0) · a predicted model of the same protein · chain B against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35222
- Every structure of UniProt Q9NQB0
- Every structure of UniProt O00512
- Elsewhere: RCSB PDB 2GL7 · PDBe 2GL7 · UniProt P35222 · UniProt Q9NQB0 · UniProt O00512
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