MolNFT v1 · #37298 · protein

Second CA2+ binding domain of the NA,CA-exchanger (NCX1)

2FWU · SODIUM/CALCIUM exchanger 1: “Second CA2+ binding domain of the NA,CA-exchanger (NCX1)”. Solution nmr, 1 ligand (CA), 1 pocket (best druggability 0.41). MolNFT v1 #37298 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2FWU
Type: protein
Length: 157 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SODIUM/CALCIUM exchanger 1
UniProt: P23685
Ligands: CA
Pockets: 1 · best druggability 0.41

Structure

solution nmr · 1 distinct chain · 4% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SODIUM/CALCIUM exchanger 1	protein	157	4% helix, 32% strand	P23685

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.41	0.74	18	empty

Compared structures

2FWU · Second Ca2+ binding domain of the Na,Ca-exchanger (NCX1) · the same entry in another collection · chain A against A, TM-score 1.00
P23685 · AlphaFold monomer V2.0 prediction for SODIUM/CALCIUM exchanger 1 (P23685) · a predicted model of the same protein · chain A against A, TM-score 0.72

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23685
Elsewhere: RCSB PDB 2FWU · PDBe 2FWU · UniProt P23685

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