MolNFT v1 · #36565 · protein
3.0 ångström resolution structure of a Y22M mutant of the spliceosomal protein P14 bound to a region of SF3B155
2F9J · Pre-mRNA branch site protein P14: “3.0 ångström resolution structure of a Y22M mutant of the spliceosomal protein P14 bound to a region of…”. X-ray diffraction, 4 pockets (best druggability 0.55). MolNFT v1 #36565 on GenesisL1: 3D…
- PDB
- 2F9J
- Type
- protein
- Length
- 290 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA branch site protein P14; Splicing factor 3B subunit 1
- UniProt
- Q9Y3B4, O75533
- Pockets
- 4 · best druggability 0.55
Structure
x-ray diffraction · 3 distinct chains · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Pre-mRNA branch site protein P14 | protein | 114 | 33% helix, 22% strand | Q9Y3B4 |
| P | Splicing factor 3B subunit 1 | protein | 35 | 51% helix, 9% strand | O75533 |
| Q | Splicing factor 3B subunit 1 | protein | 27 | 33% helix, 11% strand | O75533 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.55 | 0.79 | 28 | empty |
| 2 | 193 | 0.54 | 0.79 | 31 | empty |
| 3 | 97 | 0.41 | 0.77 | 19 | empty |
| 4 | 109 | 0.39 | 0.75 | 18 | empty |
Interfaces
2 interfaces between chains.
- A–P · 1416 Ų buried · 23 hydrogen bonds · protein-protein
- B–Q · 1349 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 2F9J · 3.0 angstrom resolution structure of a Y22M mutant of the spliceosomal protein p14 bound… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y3B4 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 6 (Q9Y3B4) · a predicted model of the same protein · chain A against A, TM-score 0.97
- O75533 · AlphaFold monomer V2.0 prediction for splicing factor 3B subunit 1 (O75533) · a predicted model of the same protein · chain Q against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y3B4
- Every structure of UniProt O75533
- Elsewhere: RCSB PDB 2F9J · PDBe 2F9J · UniProt Q9Y3B4 · UniProt O75533
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