MolNFT v1 · #31724 · protein
Crystal structure of the catalytic domain of protein tyrosine phosphatase, non-receptor type 3
2B49: “Crystal structure of the catalytic domain of protein tyrosine phosphatase, non-receptor type 3”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #31724 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2B49
- Type
- protein
- Length
- 259 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein tyrosine phosphatase, non-receptor type 3
- EC
- 3.1.3.48
- UniProt
- P26045
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein tyrosine phosphatase, non-receptor type 3 (EC 3.1.3.48) | protein | 259 | 31% helix, 26% strand | P26045 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 162 | 0.52 | 0.79 | 24 | empty |
| 2 | 80 | 0.37 | 0.76 | 14 | empty |
Compared structures
- 2B49 · Crystal Structure of the Catalytic Domain of Protein Tyrosine Phosphatase, non-receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- P26045 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 3… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26045
- Elsewhere: RCSB PDB 2B49 · PDBe 2B49 · UniProt P26045
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.