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Crystal structure of the catalytic domain of protein tyrosine phosphatase, non-receptor type 3

Analyse Crystal structure of the catalytic domain of protein tyrosine phosphatase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2B49
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein tyrosine phosphatase, non-receptor type 3
EC: 3.1.3.48
UniProt: P26045
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein tyrosine phosphatase, non-receptor type 3 (EC 3.1.3.48)	protein	259	31% helix, 26% strand	P26045

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	162	0.52	0.79	24	empty
2	80	0.37	0.76	14	empty

Compared structures

2B49 · Crystal Structure of the Catalytic Domain of Protein Tyrosine Phosphatase, non-receptor… · the same entry in another collection · chain A against A, TM-score 1.00
P26045 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 3… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26045
Elsewhere: RCSB PDB 2B49 · PDBe 2B49 · UniProt P26045

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