UniProt P26045
Tyrosine-protein phosphatase non-receptor type 3 (P26045)
Tyrosine-protein phosphatase non-receptor type 3 (UniProt P26045), EC 3.1.3.48: 24 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 12 pockets. Binding sites, druggability and experiment against…
- UniProt
- P26045
- Protein
- Tyrosine-protein phosphatase non-receptor type 3
- EC
- 3.1.3.48
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 12 · 2 records with a druggable one
Structures
25 records of P26045 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2B49 | Crystal Structure of the Catalytic Domain of Protein Tyrosine Phosphatase, non-receptor Type 3 | x-ray diffraction | A | — | — |
| 2B49 | Crystal structure of the catalytic domain of protein tyrosine phosphatase, non-receptor type 3 | x-ray diffraction | A | — | — |
| 4QUM | Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide | x-ray diffraction | A | — | — |
| 4QUM | Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide | x-ray diffraction | A | — | — |
| 4QUN | Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant | x-ray diffraction | A, B | — | — |
| 4QUN | Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant | x-ray diffraction | A, B | — | — |
| 4RH5 | Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide | x-ray diffraction | A | — | — |
| 4RH5 | Crystal structure of PTPN3 (PTPH1) in complex with EPS15 PTYR849 peptide | x-ray diffraction | A | — | — |
| 4RH9 | Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide | x-ray diffraction | A | — | — |
| 4RH9 | Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with EPS15 PTYR849 peptide | x-ray diffraction | A | — | — |
| 4RHG | Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide | x-ray diffraction | A | — | — |
| 4RHG | Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with EPS15 PTYR849 peptide | x-ray diffraction | A | — | — |
| 4RI4 | Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate | x-ray diffraction | A, B | — | — |
| 4RI4 | Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate | x-ray diffraction | A, B | — | — |
| 4RI5 | Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate | x-ray diffraction | A, B | — | — |
| 4RI5 | Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate | x-ray diffraction | A, B | — | — |
| 4S0G | Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide | x-ray diffraction | A | — | — |
| 4S0G | Crystal structure of PTPN3 (PTPH1) in complex with EPS15 PTYR849 P850V peptide | x-ray diffraction | A | — | — |
| 6HKS | Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide | x-ray diffraction | A, B, C, D, E, F | IOD | — |
| 6HKS | Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide | x-ray diffraction | A, B, C, D, E, F | IOD | — |
| 6T36 | Crystal structure of the PTPN3 PDZ domain bound to the HBV core protein C-terminal peptide | x-ray diffraction | A | BR | — |
| 6T36 | Crystal structure of the PTPN3 PDZ domain bound to the HBV core protein C-terminal peptide | x-ray diffraction | A | BR | — |
| 8CQY | Crystal structure of the PTPN3 PDZ domain bound to the PBM TACE C-terminal peptide | x-ray diffraction | A | NA | — |
| 8OEP | Crystal structure of the PTPN3 PDZ domain bound to the HPV18 E6 oncoprotein C-terminal peptide | x-ray diffraction | A, C | NA | 2 (best 0.58) |
| P26045 | AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 3 (P26045) | predicted | A | — | 10 (best 0.76) |
Ligands
Experiment against prediction
- 4RI4 chain B against the predicted model P26045: TM-score 0.99, RMSD 0.96 Å
- 4RI4 chain B against the predicted model P26045: TM-score 0.99, RMSD 0.96 Å
- 4S0G chain A against the predicted model P26045: TM-score 0.99, RMSD 0.84 Å
- 4S0G chain A against the predicted model P26045: TM-score 0.99, RMSD 0.84 Å
- 4QUM chain A against the predicted model P26045: TM-score 0.99, RMSD 0.87 Å
- 4QUM chain A against the predicted model P26045: TM-score 0.99, RMSD 0.87 Å
- 4QUN chain A against the predicted model P26045: TM-score 0.99, RMSD 1.03 Å
- 4QUN chain A against the predicted model P26045: TM-score 0.99, RMSD 1.03 Å
- 2B49 chain A against the predicted model P26045: TM-score 0.99, RMSD 0.85 Å
- 2B49 chain A against the predicted model P26045: TM-score 0.99, RMSD 0.85 Å
Elsewhere
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