MolNFT v1 · #319651 · protein
AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 3 (P26045)
P26045: “AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 3 (P26045)”. 10 pockets (best druggability 0.76). MolNFT v1 #319651 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P26045
- Type
- protein
- Length
- 913 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6Ed09D80e98fE15DE51C9E7a8896AbF1f2365C3e
- Molecule
- Tyrosine-protein phosphatase non-receptor type 3
- UniProt
- P26045
- Pockets
- 10 · best druggability 0.76
Structure
1 distinct chain · 24% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 3 | protein | 913 | 24% helix, 20% strand | P26045 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1164 | 0.76 | 0.78 | 89 | empty |
| 2 | 243 | 0.69 | 0.85 | 26 | empty |
| 3 | 371 | 0.61 | 0.77 | 44 | empty |
| 4 | 335 | 0.61 | 0.77 | 41 | empty |
| 5 | 174 | 0.54 | 0.79 | 25 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4RI5 · Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 4RI5 · Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 4QUN · Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 4QUN · Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 4RI4 · Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 4RI4 · Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 4RH9 · Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849… · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 4RH9 · Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with EPS15 PTYR849… · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 4RHG · Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849… · an experimental structure of the same protein · chain A against A, TM-score 0.31
- 4RHG · Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with EPS15 PTYR849… · an experimental structure of the same protein · chain A against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26045
- Elsewhere: UniProt P26045 · AlphaFold DB P26045
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