MolNFT v1 · #105846 · protein
Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with EPS15 PTYR849 peptide
4RH9 · Tyrosine-protein phosphatase non-receptor type 3: “Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with EPS15 PTYR849 peptide”. X-ray diffraction, 4 pockets (best druggability 0.39). MolNFT v1 #105846 on GenesisL1…
- PDB
- 4RH9
- Type
- protein
- Length
- 290 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 3; Epidermal growth factor receptor…
- EC
- 3.1.3.48
- UniProt
- P26045, P42566
- Pockets
- 4 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) | protein | 282 | 36% helix, 23% strand | P26045 |
| B | Epidermal growth factor receptor substrate 15 | protein | 8 | 0% helix, 0% strand | P42566 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.39 | 0.81 | 15 | empty |
| 2 | 91 | 0.37 | 0.75 | 17 | empty |
| 3 | 71 | 0.33 | 0.75 | 14 | empty |
| 4 | 66 | 0.31 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 532 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 4RH9 · Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849… · the same entry in another collection · chain A against A, TM-score 1.00
- P26045 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 3… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P42566 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor substrate 15… · a predicted model of the same protein · chain B against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26045
- Every structure of UniProt P42566
- Elsewhere: RCSB PDB 4RH9 · PDBe 4RH9 · UniProt P26045 · UniProt P42566
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