MolNFT v1 · #31419 · protein
Crystal structure of the GRB14 bps region in complex with the insulin receptor tyrosine kinase
2AUH: “Crystal structure of the GRB14 bps region in complex with the insulin receptor tyrosine kinase”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.67). MolNFT v1 #31419 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2AUH
- Type
- protein
- Length
- 337 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Growth factor receptor-bound protein 14
- EC
- 2.7.1.112
- UniProt
- P06213, Q14449
- Ligands
- CA
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor (EC 2.7.1.112) | protein | 300 | 36% helix, 18% strand | P06213 |
| B | Growth factor receptor-bound protein 14 | protein | 37 | 43% helix, 14% strand | Q14449 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 432 | 0.67 | 0.79 | 43 | CA |
| 2 | 80 | 0.48 | 0.82 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1233 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (phosphorylation).
Compared structures
- 2AUH · Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine… · the same entry in another collection · chain A against A, TM-score 1.00
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain A against A, TM-score 0.92
- Q14449 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 14 (Q14449) · a predicted model of the same protein · chain B against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt Q14449
- Elsewhere: RCSB PDB 2AUH · PDBe 2AUH · UniProt P06213 · UniProt Q14449
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