Research workbench
Crystal structure of the GRB14 bps region in complex with the insulin receptor tyrosine kinase
Analyse Crystal structure of the GRB14 bps region in complex with the insulin receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AUH
- Type
- protein
- Length
- 337 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Growth factor receptor-bound protein 14
- EC
- 2.7.1.112
- UniProt
- P06213, Q14449
- Ligands
- CA
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor (EC 2.7.1.112) | protein | 300 | 36% helix, 18% strand | P06213 |
| B | Growth factor receptor-bound protein 14 | protein | 37 | 43% helix, 14% strand | Q14449 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 432 | 0.67 | 0.79 | 43 | CA |
| 2 | 80 | 0.48 | 0.82 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1233 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (phosphorylation).
Compared structures
- 2AUH · Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine… · the same entry in another collection · chain A against A, TM-score 1.00
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain A against A, TM-score 0.92
- Q14449 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 14 (Q14449) · a predicted model of the same protein · chain B against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt Q14449
- Elsewhere: RCSB PDB 2AUH · PDBe 2AUH · UniProt P06213 · UniProt Q14449
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