MolNFT v1 · #21295 · protein
Structure of scallop myosin S1 reveals a novel nucleotide conformation
1S5G · Myosin heavy chain, striated muscle: “Structure of scallop myosin S1 reveals a novel nucleotide conformation”. X-ray diffraction, 4 ligands (ADP, CA, MG), 11 pockets (best druggability 0.79). MolNFT v1 #21295 on GenesisL1: 3D…
- PDB
- 1S5G
- Type
- protein
- Length
- 1,099 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin heavy chain, striated muscle; Myosin regulatory light chain, striated adductor…
- UniProt
- P24733, P13543, P07291
- Ligands
- ADP, CA, MG, SO4
- Pockets
- 11 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin heavy chain, striated muscle | protein | 802 | 47% helix, 13% strand | P24733 |
| Y | Myosin regulatory light chain, striated adductor muscle | protein | 142 | 38% helix, 4% strand | P13543 |
| Z | Myosin essential light chain, striated adductor muscle | protein | 155 | 50% helix, 5% strand | P07291 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- CA · Calcium ion · metal · chains Z
- MG · Magnesium ion · metal · chains Y
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 953 | 0.79 | 0.81 | 107 | SO4, ADP |
| 2 | 270 | 0.76 | 0.88 | 34 | empty |
| 3 | 62 | 0.67 | 0.94 | 20 | empty |
| 4 | 522 | 0.65 | 0.77 | 56 | empty |
| 5 | 249 | 0.57 | 0.78 | 33 | empty |
Interfaces
3 interfaces between chains.
- A–Z · 2081 Ų buried · 18 hydrogen bonds · protein-protein
- A–Y · 1709 Ų buried · 15 hydrogen bonds · protein-protein
- Y–Z · 223 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1S5G · Structure of Scallop myosin S1 reveals a novel nucleotide conformation · the same entry in another collection · chain A against A, TM-score 1.00
- P07291 · AlphaFold monomer V2.0 prediction for myosin essential light chain, striated adductor… · a predicted model of the same protein · chain Z against A, TM-score 0.97
- P13543 · AlphaFold monomer V2.0 prediction for myosin regulatory light chain, striated adductor… · a predicted model of the same protein · chain Y against A, TM-score 0.84
- P24733 · AlphaFold monomer V2.0 prediction for myosin heavy chain, striated muscle (P24733) · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24733
- Every structure of UniProt P13543
- Every structure of UniProt P07291
- Elsewhere: RCSB PDB 1S5G · PDBe 1S5G · UniProt P24733 · UniProt P13543 · UniProt P07291
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.