Escherichia COLI ferric hydroxamate uptake receptor (fhua) in complex delta two-albomycin

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 54% strand (DSSP).

Ligands and binding sites

• FTT · 3-hydroxy-tetradecanoic acid · ligand · 6 copies · chains A
• DPO · Diphosphate · ligand · 2 copies · chains A
• PA1 · 2-amino-2-deoxy-alpha-D-glucopyranose · ligand · chains A
• GCN · 2-amino-2,3-dideoxy-alpha-D-glucoyranose · ligand · chains A
• ALB · Delta-2-albomycin A1 · ligand · chains A
• GMH · L-glycero-alpha-D-manno-heptopyranose · sugar · 3 copies · chains A
• GLC · alpha-D-glucopyranose · sugar · 3 copies
• KDO · 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid · sugar · 2 copies · chains A
• GLA · alpha-D-galactopyranose · sugar
• NI · Nickel (II) ion · metal
• PO4 · Phosphate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

• 1QKC · Escherichia COLI ferric hydroxamate uptake receptor (fhua) in complex delta two-albomycin · the same entry in another collection · chain A against A, TM-score 1.00
• P06971 · AlphaFold monomer V2.0 prediction for ferrichrome outer membrane TRANSPORTER/PHAGE… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P06971
• Elsewhere: RCSB PDB 1QKC · PDBe 1QKC · UniProt P06971