MolNFT v1 · #190642 · protein
Structural insights into human brain gut peptide cholecystokinin receptors
7XOX · GASTRIN/CHOLECYSTOKININ type B receptor: “Structural insights into human brain gut peptide cholecystokinin receptors”. Electron microscopy, 13 pockets (best druggability 0.82). MolNFT v1 #190642 on GenesisL1: 3D structure, binding…
- PDB
- 7XOX
- Type
- protein
- Length
- 1,122 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GASTRIN/CHOLECYSTOKININ type B receptor; Guanine nucleotide-binding protein…
- UniProt
- P32239, P62873, P59768, P50148
- Pockets
- 13 · best druggability 0.82
Structure
electron microscopy · 6 distinct chains · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | GASTRIN/CHOLECYSTOKININ type B receptor | protein | 276 | 79% helix, 0% strand | P32239 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 7% helix, 47% strand | P62873 |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 51 | 49% helix, 0% strand | P59768 |
| E | SCFV16 | protein | 230 | 1% helix, 46% strand | — |
| A | Guanine nucleotide-binding protein G(Q) subunit alpha | protein | 219 | 42% helix, 16% strand | P50148 |
| L | Cck-8 | protein | 8 | 0% helix, 0% strand | — |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 793 | 0.82 | 0.85 | 65 | empty |
| 2 | 556 | 0.63 | 0.75 | 52 | empty |
| 3 | 160 | 0.57 | 0.82 | 28 | empty |
| 4 | 173 | 0.53 | 0.79 | 30 | empty |
| 5 | 92 | 0.49 | 0.82 | 24 | empty |
Interfaces
6 interfaces between chains.
- B–C · 2021 Ų buried · 10 hydrogen bonds · protein-protein
- B–A · 1283 Ų buried · 10 hydrogen bonds · protein-protein
- R–A · 1075 Ų buried · 8 hydrogen bonds · protein-protein
- R–L · 904 Ų buried · 11 hydrogen bonds · protein-protein
- E–A · 580 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide, 1 modified (disulfide, sulfation).
Compared structures
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P32239 · AlphaFold monomer V2.0 prediction for GASTRIN/CHOLECYSTOKININ type B receptor (P32239) · a predicted model of the same protein · chain R against A, TM-score 0.93
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.89
- P50148 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(Q) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32239
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P50148
- Elsewhere: RCSB PDB 7XOX · PDBe 7XOX · UniProt P32239 · UniProt P62873 · UniProt P59768 · UniProt P50148
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