UniProt P50148
Guanine nucleotide-binding protein G(q) subunit alpha (P50148)
Guanine nucleotide-binding protein G(q) subunit alpha (UniProt P50148): 26 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 120 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P50148
- Protein
- Guanine nucleotide-binding protein G(q) subunit alpha
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 120 · 19 records with a druggable one
Structures
27 records of P50148 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6VU5 | Structure of G-alpha-q bound to its chaperone Ric-8A | electron microscopy | B | — | 6 (best 0.60) |
| 6VU5 | Structure of G-alpha-Q bound to its chaperone ric-8A | electron microscopy | B | — | — |
| 7EZM | Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex | electron microscopy | A | — | 9 (best 0.82) |
| 7EZM | Cryo-EM structure of an activated cholecystokinin a receptor (cckar)- gq complex | electron microscopy | A | — | — |
| 7F6H | Cryo-EM structure of human bradykinin receptor BK2R in complex gq proteins and bradykinin | electron microscopy | B | — | — |
| 7F6I | Cryo-EM structure of human bradykinin receptor BK2R in complex Gq proteins and kallidin | electron microscopy | B | — | 5 (best 0.82) |
| 7F6I | Cryo-EM structure of human bradykinin receptor BK2R in complex gq proteins and kallidin | electron microscopy | B | — | — |
| 7F8W | Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq | electron microscopy | A | — | 9 (best 0.82) |
| 7F8W | Cryo-EM structure of the cholecystokinin receptor cckbr in complex with gastrin-17 and gq | electron microscopy | A | — | — |
| 7W3Z | Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Gastrin… | electron microscopy | B | — | 9 (best 0.82) |
| 7W40 | Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Bombesin… | electron microscopy | B | — | 10 (best 0.82) |
| 7XOW | Structural insights into human brain gut peptide cholecystokinin receptors | electron microscopy | A | — | — |
| 7XOX | Structural insights into human brain gut peptide cholecystokinin receptors | electron microscopy | A | — | — |
| 8G59 | Cryo-EM structure of the TUG891 bound GPR120-Giq complex | electron microscopy | A | — | 7 (best 0.82) |
| 8IYS | TUG891-bound FFAR4 in complex with Gq | electron microscopy | A | GDP | 6 (best 0.82) |
| 8J9N | Gq bound FZD1 in ligand-free state | electron microscopy | C | — | 6 (best 0.82) |
| 8JPC | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 | electron microscopy | Q | GDP, MG, ALF | 4 (best 0.76) |
| 8SZG | Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gq complex in lipid… | electron microscopy | C | — | 5 (best 0.81) |
| 8THK | Cryo-EM structure of A61603-bound alpha-1A-adrenergic receptor in complex with heterotrimeric… | electron microscopy | A | — | 5 (best 0.82) |
| 8THL | Cryo-EM structure of epinephrine-bound alpha-1A-adrenergic receptor in complex with heterotrimeric… | electron microscopy | A | — | 5 (best 0.81) |
| 8UQN | PLCb3-Gaq complex on membranes | electron microscopy | A | GDP, ALF, MG | 4 (best 0.81) |
| 8UQO | PLCb3-Gbg-Gaq complex on membranes | electron microscopy | A | GDP, ALF, MG | 3 (best 0.81) |
| 8XGO | a peptide receptor complex structure | electron microscopy | E | — | 8 (best 0.81) |
| 8XGS | a peptide receptor complex structure | electron microscopy | E | — | 8 (best 0.81) |
| 8ZJD | Cryo-EM structure of kisspeptin receptor bound to KP-10 | electron microscopy | A | — | 6 (best 0.82) |
| 8ZJE | Cryo-EM structure of kisspeptin receptor bound to TAK-448 | electron microscopy | A | — | 5 (best 0.83) |
| P50148 | AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(Q) subunit alpha (P50148) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8UQN chain A against the predicted model P50148: TM-score 0.98, RMSD 0.82 Å
- 8UQO chain A against the predicted model P50148: TM-score 0.98, RMSD 0.83 Å
- 8JPC chain Q against the predicted model P50148: TM-score 0.98, RMSD 0.92 Å
- 8IYS chain A against the predicted model P50148: TM-score 0.92, RMSD 2.33 Å
- 7W3Z chain B against the predicted model P50148: TM-score 0.87, RMSD 2.73 Å
- 8G59 chain A against the predicted model P50148: TM-score 0.87, RMSD 2.39 Å
- 7EZM chain A against the predicted model P50148: TM-score 0.87, RMSD 2.48 Å
- 7EZM chain A against the predicted model P50148: TM-score 0.87, RMSD 2.48 Å
- 7W40 chain B against the predicted model P50148: TM-score 0.86, RMSD 2.72 Å
- 7F6H chain B against the predicted model P50148: TM-score 0.86, RMSD 2.52 Å
Elsewhere
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