MolNFT v1 · #189914 · protein
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-gq protein complex
7W53 · Guanine nucleotide-binding protein G(Q) subunit alpha: “Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-gq protein complex”. Electron microscopy, 12 pockets (best druggability 0.82). MolNFT v1 #189914 on…
- PDB
- 7W53
- Type
- protein
- Length
- 1,108 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(Q) subunit alpha; Guanine nucleotide-binding protein…
- UniProt
- P62873, P48645, P59768
- Pockets
- 12 · best druggability 0.82
Structure
electron microscopy · 6 distinct chains · 35% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(Q) subunit alpha | protein | 210 | 45% helix, 19% strand | — |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 8% helix, 46% strand | P62873 |
| C | Neuromedin-U-25 | protein | 7 | 0% helix, 0% strand | P48645 |
| E | SCFV16 | protein | 232 | 6% helix, 47% strand | — |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 57 | 54% helix, 0% strand | P59768 |
| R | Neuromedin-U receptor 1 | protein | 264 | 82% helix, 2% strand | — |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 670 | 0.82 | 0.87 | 56 | empty |
| 2 | 192 | 0.77 | 0.92 | 33 | empty |
| 3 | 760 | 0.72 | 0.78 | 56 | empty |
| 4 | 373 | 0.66 | 0.80 | 55 | empty |
| 5 | 213 | 0.55 | 0.79 | 31 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2135 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1411 Ų buried · 20 hydrogen bonds · protein-protein
- A–R · 1036 Ų buried · 8 hydrogen bonds · protein-protein
- C–R · 778 Ų buried · 18 hydrogen bonds · protein-protein
- A–E · 517 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7W53 · Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex · the same entry in another collection · chain R against R, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.96
- P48645 · AlphaFold monomer V2.0 prediction for neuromedin-U (P48645) · a predicted model of the same protein · chain C against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62873
- Every structure of UniProt P48645
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7W53 · PDBe 7W53 · UniProt P62873 · UniProt P48645 · UniProt P59768
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